5-Bromouracil
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5-Bromouracil 속성
- 녹는점
- >300 °C (lit.)
- 밀도
- 1.8710 (rough estimate)
- 굴절률
- 1.6200 (estimate)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- <1g/L
- 산도 계수 (pKa)
- 6.77±0.10(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- 수용성
- 냉수에 용해됨
- Merck
- 14,1445
- BRN
- 127176
- InChIKey
- LQLQRFGHAALLLE-UHFFFAOYSA-N
- CAS 데이터베이스
- 51-20-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-46 | ||
안전지침서 | 36/37-53-45-24/25 | ||
WGK 독일 | 3 | ||
RTECS 번호 | YQ9060000 | ||
TSCA | Yes | ||
HS 번호 | 29335995 | ||
유해 물질 데이터 | 51-20-7(Hazardous Substances Data) |
5-Bromouracil C화학적 특성, 용도, 생산
개요
5-bromouracil (5-BU) is a uracil derivative, and its 5' position of the pyrimidine ring is halogenated. If 5-BU is incorporated into DNA in place of thymine, the tautomeric shift will occur, and the 5-BU will base pair with guanine. After the replication, an A-T to G-C transition occurs. Furthermore, the presence of 5-BU within DNA increases the sensitivity of the molecule to UV light. 5-BU is structurally similar to thymine. Therefore, it is considered a thymine analog and base-pairs normally with adenine. It is rarely present in its enol form, where its base pairs with guanine. 5-Bromouracil treats neoplasms in the form of its nucleoside, 5-bromo-2-deoxy-uridine[1-2].화학적 성질
Prisms from H 2 O.용도
A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine정의
ChEBI: A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position.일반 설명
White powder.공기와 물의 반응
Insoluble in water.반응 프로필
A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).위험도
Moderately toxic, alters DNA by replacing thymine.건강위험
ACUTE/CHRONIC HAZARDS: When heated to decomposition 5-Bromouracil emits very toxic fumes of bromide ion and NOx.화재위험
Flash point data for 5-Bromouracil are not available, but 5-Bromouracil is probably combustible.Safety Profile
Moderately toxic by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Brand NOx.5-Bromouracil 준비 용품 및 원자재
원자재
준비 용품
5-Bromouracil 공급 업체
글로벌( 520)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 |
info@jiuwuchem.cn | China | 75 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 |
sales@zhswyy.com | China | 301 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16208 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21671 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2141 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 906 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
5-Bromouracil 관련 검색:
우라실 브로마실 브롬
5-Bromopyrimidine
5-Bromouridine
Broxuridine
5-Bromo-2'-deoxy-5'-uridylic acid disodium salt
5-Bromouracil-6-carboxylic acid
5-bromo-2',3'-dideoxyuridine
6-amino-5-bromouraci
1-amino-5-bromouracil
5-BROMOURIDINE 5'-TRIPHOSPHATE SODIUM SALT
3',5'-DI-O-ACETYL-5-BROMO-2'-DEOXY-D-URIDINE
5-BROMO-1,3-DIMETHYLURACIL
5-BROMO-2'-DEOXYURIDINE 5'-TRIPHOSPHATE SODIUM SALT
6-Amino-1-benzyl-5-bromouracil
5-BROMO-6-METHYLURACIL
1,3,6-TRIMETHYL-5-BROMOURACIL