리탄세린
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리탄세린 속성
- 녹는점
- 145.5°
- 끓는 점
- 618.7±65.0 °C(Predicted)
- 밀도
- 1.30±0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- 메탄올: >10mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 7.74±0.20(Predicted)
- 색상
- 하얀색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-26-36 | ||
| WGK 독일 | 3 | ||
| 독성 | LD50 in male, female mice, rats, dogs (mg/kg): 28.2, 28.2, 20.0, 22.2, 24.1, 33.2 i.v.; 626, 993, 956, 515, ~1280, 640-1280 orally (Awouters) |
리탄세린 C화학적 특성, 용도, 생산
개요
Ritanserin, also known by its developmental code name R-55667, is a serotonin antagonist medication described as an anxiolytic, antidepressant, antiparkinsonian agent, and antihypertensive agent. It was never marketed for medical use due to safety problems but has been used in scientific research to study the serotonin system.용도
Ritanserin and other 5HT2A/2C receptor antagonists have shown in clinical trial to promote slow-wave sleep in chronic primary insomnia or generalized anxiety disorder (Mayer, 2003).용도
Ritanserin has been used in behavioral testing and as a serotonin 2A receptor (5-HT2A)-receptor antagonist.정의
ChEBI: Ritanserin is a thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. It has a role as a dopaminergic antagonist, a serotonergic antagonist, an antipsychotic agent, an anxiolytic drug, an antidepressant and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is an organofluorine compound, a member of piperidines and a thiazolopyrimidine.위험도
A poison.생물학적 활성
Ritanserin acts as a potent and long-acting 5-HT 2 receptor; antagonist (Ki = 0.39nM).Anxiolytic in vivo .It has relatively low affinity for the H1, D2, α1-adrenergic, and α2-adrenergic receptors (39-, 77-, 107-, and 166-fold lower relative to 5-HT2A, respectively).리탄세린 준비 용품 및 원자재
원자재
준비 용품
리탄세린 공급 업체
글로벌( 78)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16209 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 |
chem1022@hengdian-group.com | China | 1478 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10978 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
리탄세린 관련 검색:
1-Fluoro-4-(1-methylethenyl)benzene
Ritanserin
4-Pyrimidinol
4-[(4-Fluorophenyl)methylene]piperidine
4-Hydroxy-6-methylpyrimidine
2-Methylthio-4-pyrimidinol
4,4'-Difluorodiphenylmethane
6-Methyl-2-(methylthio)pyrimidin-4-ol
4-Fluorostyrene
N,N-DIMETHYLMETHACRYLAMIDE
DIACYLGLYCEROL KINASE INHIBITOR I
4-(DIPHENYLMETHYLENE)PIPERIDINE
1-Methyl-4-methylene-piperidine
4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-
1,1-BIS(4-FLUOROPHENYL)-1-BUTENE
7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
N,N'-DIMETHYLCARBAMIMINOTHIOIC ACID METHYL ESTER
Ketanserin/Ritanserin/Sufrexal/Serefrex