GW501516
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GW501516 속성
- 녹는점
- 134 - 144°C
- 저장 조건
- Refrigerator
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 연한 노란색
안전
GW501516 C화학적 특성, 용도, 생산
생물학적 활성
GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.Synthesis
Add Cs2CO3 (3.25 g, 10.0 mmol), followed by the chloromethylthiazole (2.60 g) to a stirred solution of 4-mercapto-2-methylphenol (1.40 g) in CH3CN (80 mL). Stir the reaction mixture at room temperature for 4 hours. Add Cs2CO3 (4.89 g, 15.0 mmol), followed by methyl bromoacetate (1.23 mL, 13.0 mmol) to the mixture. Stir the reaction mixture at room temperature for another 5 hours. Pour the mixture into water. Extract the mixture with EtOAc (3 x 100 mL). Combine the organic layers. Wash the organic layers with brine. Dry the organic layers (Na2SO4). Concentrate the organic layers. Purify the residue by column chromatography on silica gel with hexane/ ethyl acetate (5:1). 1H NMR (CDCl3) δ7.97 (d, 2H, J= 8.4 Hz), 7.65 (d, 2H, J= 8.4 Hz), 7.21 (d, 1H, J= 2.4 Hz), 7.13 (dd, 1H, J= 8.4, 2.4 Hz), 6.58 (d, 1H, J= 8.4 Hz), 4.63 (s, 2H), 4.11 (s, 2H), 3.78 (s, 3H), 2.24 (s, 3H), 2.20 (s, 3H). 13C NMR (CDCl3) δ169.2, 163.0, 156.3, 151.3, 136.8, 136.1, 132.1, 131.2 (q, J= 32 Hz), 130.6, 128.4, 126.3, 125.8 (q, J= 4 Hz), 125.3, 122.1, 111.4, 65.4, 52.2, 32.4, 16.1, 14.8. 19F NMR (CDCl3) δ115.5 (s).Fig. The synthetic step 1 of GW-501516
GW501516 준비 용품 및 원자재
원자재
준비 용품
GW501516 공급 업체
글로벌( 59)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hubei Langyou International Trading Co., Ltd | +86-18874586545 +86-18874586545 |
linda@xrdchem.cn | China | 197 | 58 |
Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 |
sales@whaop.com | China | 265 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12558 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Guangdong Tuoyuan Biotechnology Co., LTD | +85267545345 |
sterodschina@gmail.com | China | 152 | 58 |
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 |
wangwendy93@gmail.com | China | 868 | 58 |
Hebei Qige Biological Technology Co. Ltd | +86 +8618733132031 |
CHINA | 1313 | 58 | |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 23499 | 58 |
Wuhan Golt Biotech Co., Ltd. | +8615389281203 |
maria@goltbiotech.com | China | 980 | 58 |
Shanghai Qianyi New Material Co., Ltd. | +8618083322317 |
3391883138@qq.com | China | 878 | 58 |