그라미시딘C

그라미시딘C
그라미시딘C 구조식 이미지
카스 번호:
113-73-5
한글명:
그라미시딘C
동의어(한글):
그라미시딘C
상품명:
GRAMICIDIN C
동의어(영문):
GRAMICIDIN S;Gramicidin S-A;GRAMICIDIN C;Gramicidin S1;Soviet Gramicidin C;Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-);Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-);HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH
CBNumber:
CB6759311
분자식:
C60H92N12O10
포뮬러 무게:
1141.45
MOL 파일:
113-73-5.mol

그라미시딘C 속성

녹는점
265-270 °C (decomp)(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
끓는 점
827.42°C (rough estimate)
밀도
1.0265 (rough estimate)
굴절률
1.6000 (estimate)
산도 계수 (pKa)
13.00±0.70(Predicted)
물리적 상태
Solid
색상
White to off-white
optical activity
-28924 (70% ethanol)
수용성
0.14g/L(28℃)
InChIKey
IUAYMJGZBVDSGL-XNNAEKOYSA-N

안전

그라미시딘C C화학적 특성, 용도, 생산

개요

Gramicidin S was found in the culture broth of Bacillus brevis by Gause of the USSR Academy of Medical Sciences in 1944. It was later found by Otani of Osaka University in the cells of the Nagano strain of the same species. The antibiotic is a basic peptide showing strong activity against gram-positive bacteria and considerable activity against gramnegative cocci and Mycobacterium. Gramicidin S is rather toxic but is not absorbed orally; it is used topically as an ointment or as eye or ear drops in combination with other antibacterial drugs.

정의

A cyclic peptide that acts on gram-positive bacteria.

Purification Methods

Gramicidin S crystallises from EtOH. The di-HCl crystallises from EtOH (+ few drops of HCl) with m 277-278o (see below). [NMR: Gibbons et al. Nature 227 840 1970, Beilstein 26 III/IV 4273.]

그라미시딘C 준비 용품 및 원자재

원자재

준비 용품


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