ACPT-I
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ACPT-I 속성
- 끓는 점
- 440.4±45.0 °C(Predicted)
- 밀도
- 1.651±0.06 g/cm3(Predicted)
- 저장 조건
- Desiccate at -20°C
- 용해도
- Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 1.85±0.60(Predicted)
안전
ACPT-I C화학적 특성, 용도, 생산
개요
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.생물학적 활성
Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.ACPT-I 준비 용품 및 원자재
원자재
준비 용품
ACPT-I 공급 업체
글로벌( 25)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 |
3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24647 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 4679 | 58 |