피코페린

피코페린 C화학적 특성, 용도, 생산

Originator

Coben ,Takeda, Japan,1971

Manufacturing Process

To a simultaneously stirred and refluxed suspension of 5.6 parts by weight of sodamide in 60 parts by volume of anhydrous toluene, there is added dropwise a solution of 18.4 parts by weight of N-(2-pyridylmethyl)aniline in 20 parts by volume of anhydrous toluene. After the addition is complete, the mixture is refluxed for two hours under constant stirring.
To the resulting mixture there is added dropwise a solution of 14.9 parts by weight of 2-piperidinoethyl chloride in 20 parts by volume of anhydrous toluene and the whole mixture is stirred and refluxed for another two hours. After cooling, water is added carefully to decompose the unreacted sodamide, the separated toluene layer is dried over anhydrous sodium sulfate and the solvent removed under reduced pressure.
The residual oil is subjected to distillation under reduced pressure, the fraction boiling in the range of 185°C to 198°C/4 mm Hg being collected. Purification of the fraction by redistillation under reduced pressure gives 22.5 parts by weight of N-(2-piperidinoethyl)-N-(2-pyridylmethyl)-aniline which boils at 195°C to 196°C/4 mm Hg. Yield 76.3%.

Therapeutic Function

Antitussive

피코페린 준비 용품 및 원자재

원자재

준비 용품

피코페린 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	1821	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	25655	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

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