니코틴산,3,7-디하이드로-1,3-디메틸-7-[2-[(3-피리딜메틸)아미노]에틸]-1H-퓨린-2,6-디온(1:1)과의화합물

니코틴산,3,7-디하이드로-1,3-디메틸-7-[2-[(3-피리딜메틸)아미노]에틸]-1H-퓨린-2,6-디온(1:1)과의화합물 C화학적 특성, 용도, 생산

Originator

Teonicon, Bracco, Italy ,1975

Manufacturing Process

77 g 7-(β-bromoethyl)-theophylline (C.A. 50, 12071f) and 57.8 g 3picolylamine in 750 ml toluene were refluxed 16 hours with vigorous agitation. The 3-picolylamine hydrobromide formed was filtered off, and the filtrate was evaporated in a vacuum to about one-third of its original volume. About 300 to 400 ml diisopropyl ether were added, and the solution was seeded with a few pure crystals of the desired product.
7-(β-3'-picolylaminoethyl)-theophylline crystallized over a period of a few hours. It was filtered off with suction, washed with a little diisopropyl ether, and dried. The yield of crude product was 69.3 g (82%), its MP 103° to 106°C. The MP was 111° to 112°C after recrystallization from isopropyl acetate. The compound was identified by microanalysis.
39.3 g 7-(β-3'-picolylaminoethyl)-theophylline were dissolved in 300 ml boiling isopropanol, and 15.4 g nicotinic acid were added to the solution in which the acid promptly dissolved. The nicotinate formed crystallized after a short time. It was filtered with suction and dried. The yield was 52.3 g (95.5%). The MP of 159° to 160°C was not significantly changed by recrystallization from ethanol.

Therapeutic Function

Coronary vasodilator

니코틴산,3,7-디하이드로-1,3-디메틸-7-[2-[(3-피리딜메틸)아미노]에틸]-1H-퓨린-2,6-디온(1:1)과의화합물 준비 용품 및 원자재

원자재

준비 용품

니코틴산,3,7-디하이드로-1,3-디메틸-7-[2-[(3-피리딜메틸)아미노]에틸]-1H-퓨린-2,6-디온(1:1)과의화합물 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Shaanxi Dideu Newmaterial Co., Ltd.	029-87576359 15353716720	1039@dideu.com	China	10011	58