ChemicalBook >제품 카탈로그 >트라폭신A

트라폭신A

트라폭신A 구조식 이미지

카스 번호:: 133155-89-2

한글명:: 트라폭신A

동의어(한글):: 트라폭신A

상품명:: trapoxin A

동의어(영문):: RF-1023A;trapoxin A;Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-];Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl);Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];(4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone

CBNumber:: CB71316516

분자식:: C34H42N4O6

포뮬러 무게:: 602.72

MOL 파일:: 133155-89-2.mol

속성

안전

용도

공급 업체 8

트라폭신A 속성

저장 조건: -20°C

용해도: DMSO: 용해성 0.9-1.10 mg/ml, 투명, 무색 ~ 희미한 노란색(H2O에 20배 더 희석할 수 있음)

물리적 상태: 고체

물리적 상태: 단단한 모양

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T
위험 카페고리 넘버	25
안전지침서	45
유엔번호(UN No.)	UN 2811 6.1 / PGIII
WGK 독일	3

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

P301+P310

삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

트라폭신A C화학적 특성, 용도, 생산

개요

Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC₅₀ = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml. It also halts the cell cycle at the G₂ phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A at a concentration of 50 ng/ml.

용도

Trapoxin A has been used:

to study its effects on the inhibition of histone deacetylase 11 (HDAC11)
to study its effects on the inhibition of HDAC3 in human cell lines
to study its effects on the inhibition of HDAC6 in rat pyramidal neurons

정의

ChEBI: A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues.

트라폭신A 준비 용품 및 원자재

원자재

준비 용품

트라폭신A 공급 업체

글로벌( 8)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
InvivoChem	13549236410	sales@invivochem.cn	China	6747	58

트라폭신A 관련 검색:

사이클렌 Pipecolamide ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE N-methylpiperidine-2-carboxamide trapoxin A N-(PIPERIDINOETHYL)ETHYLENEDIAMINE 2-(2-methylpiperidin-1-yl)ethanamine 1-ethylpiperidine-2-methylamine CHEMBRDG-BB 4015189 (1-BUTYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE N-[(1-BUTYL-2-PIPERIDINYL)METHYL]ETHANAMINE ETHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE N-[(1-ETHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE ETHYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE N-[(1-PROPYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE BUTYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE BUTYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE (1-ETHYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE