7-케토콜레스테롤
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7-케토콜레스테롤 속성
- 녹는점
- 158-160°C
- 끓는 점
- 463.26°C (rough estimate)
- 밀도
- 1.0044 (rough estimate)
- 굴절률
- 1.4480 (estimate)
- 저장 조건
- room temp
- 용해도
- 아세토니트릴(약간 용해됨), 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 14.68±0.70(Predicted)
- 색상
- CHCl3/Et2O에서 얻은 결정
안전
WGK 독일 | 3 | ||
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RTECS 번호 | FZ8708000 |
7-케토콜레스테롤 C화학적 특성, 용도, 생산
개요
7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL. It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by the cytochrome P450 (CYP) isoform CYP7A1. 7-keto Cholesterol inhibits CYP7A1 (IC50 = ~1 μM). It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro. Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye. Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer''s disease, and age-related macular degeneration.화학적 성질
Off-White Solid용도
A metabolite of Cholesterol정의
ChEBI: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.일반 설명
7-ketocholesterol is a major oxidation product of cholesterol.Safety Profile
Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes7-케토콜레스테롤 준비 용품 및 원자재
원자재
준비 용품
7-케토콜레스테롤 공급 업체
글로벌( 99)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3777 | 58 |
Aktin Chemicals, Inc. | 028-85159085 |
info@aktinchem.com | CHINA | 1025 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8722 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Taopu Industrial Co., LTD | 18018507602 15900573766 |
394643792@qq.com | China | 3031 | 58 |
Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 |
info@bwtlab.com | China | 9255 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 94658 | 76 |
Beijing HwrkChemical Technology Co., Ltd | 010-89508211 18501085097 |
sales.bj@hwrkchemical.com | China | 8415 | 55 |
7-케토콜레스테롤 관련 검색:
콜레스테롤
5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
25-HYDROXYCHOLESTEROL
7BETA-HYDROXYCHOLESTEROL
7-KETOCHOLESTEROL ACETATE
22-KETOCHOLESTEROL
22-KETOCHOLESTEROL ACETATE
5-CHOLESTEN-3-BETA-OL-7-ONE BENZOATE
7-oxocholest-5-en-3-beta-yl acetate
25-HYDROXYCHOLESTEROL, 7-KETONE
7-KETO CHOLESTEROL, [1,2-3H]
5-CHOLESTEN-3-BETA, 25-DIOL-7-ONE ACETATE
7-KETOCHOLESTEROL
7-KETOCHOLESTEROL-D7,7-KETOCHOLESTEROL-25,26,26,26,27,27,27-D7
5,25R-SPIROSTEN-3BETA-OL-7-ONE