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ChemicalBook >제품 카탈로그 >API>항생제>기타 항생제 약물>[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A
[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A 구조식 이미지
카스 번호:
37248-47-8
한글명:
[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A
동의어(한글):
[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨;발리다마이신A;[1S-(1.alpha.,4.alpha.,5.beta.,6.alpha.)]-1,5,6-트리데옥시-4-o-.beta.-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨;발리다마이신A;발리다마이신 A
상품명:
Validamycin
동의어(영문):
VALIDAMYCIN A;MYCIN;SOLACOL;valimon;t-7545-a;VALIDACIN;VALIDAMYCIN;Validacin[R];jiangonmycin;VALDIDAMYCIN
CBNumber:
CB7236710
분자식:
C20H35NO13
포뮬러 무게:
497.49
MOL 파일:
37248-47-8.mol
MSDS 파일:
SDS

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A 속성

녹는점
130-135°C
알파
D24 +110° (c = 1 in water or pyridine), +92° (c = 1 in DMF)
끓는 점
813.7±65.0 °C(Predicted)
밀도
1.69±0.1 g/cm3(Predicted)
증기압
Neglible at room temperature
저장 조건
0-6°C
용해도
DMSO: 2 mg/ml; PBS (pH 7.2): 10 mg/ml
물리적 상태
액체
수용성
쉽게 용해되는
산도 계수 (pKa)
6.0(at 25℃)
색상
White to off-white
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
유해 물질 데이터 37248-47-8(Hazardous Substances Data)
기존화학 물질 KE-34186
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
예방조치문구:
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A C화학적 특성, 용도, 생산

개요

Validamycin A is produced by the fermentation of Streptomyces hygroscopicus var. limoneus nov. var (30). Structure revised (31). Colorless, odorless, hygroscopic powder. V.p. Negligible at room temperature. Solubility: Readily soluble in water, soluble in methanol, dimethylformamide and dimethyl sulfoxide. Slightly soluble in ethanol and acetone. Sparingly soluble in diethyl ether and ethyl acetate. pKa 6.0 Stability [α]24D + 110? (water).

용도

Validamycin A is the major analogue of a family of cyclitol disaccharides isolated from Streptomyces hygroscopicus var. limoneus by researchers at Takeda in 1970. Although commonly regarded as an aminoglycoside, validamycin shares little in common with conventional aminoglycosides such as streptomycin and gentamicin. Validamycin A is a potent antifungal agent and is used to control fungi in crop production. Validamycin A acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi.

정의

ChEBI: A member of the class of validamycins that is (1R,2S,3S,4S,6R)-4-amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol in which the hydroxy group at position 1 has been converted to its beta-D-glucoside and in which one of the hydrogens attached to the nitrogen is replaced by a (1R,4R,5R,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cycloh x-2-en-1-yl group. It is the major validamycin produced by Streptomyces hygroscopicus.

주요 응용

Validamycin was found in the culture broth of Streptomyces hygroscopicus var. limoneus by Takeda Chemicals Industries in 1971 in the course of screening for substances active against sheath blight in the rice plant. It consists of five components. The major component, validamycin A, was found to be the major contributor to the activity. Validamycin is active against a variety of phytopathogenic fungi, especiallyPellicularia sasakii, and it has been used to protect rice plants against sheath blight.

Pharmacology

Validamycin A specifically inhibits trehalase in R. solani AG-1 in a competitive manner between validoxylamine A (the possible active form of validamycin A) and the substrate, trehalose (33). Because trehalose is a storage carbohydrate in some fungi, trehalase is suggested to play an essential role for the digestion of trehalose to D-glucose and for its transportation to the hyphal tips (34).

신진 대사 경로

Validamycin A is an effective fungistatic (as opposed to fungicidal) antibiotic which has a very low toxicity to mammals and fish. This is presumably a consequence of its selective mode of action, the inhibition of trehalase. It is readily degraded under environmental conditions.

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A 준비 용품 및 원자재

원자재

잔토프테린

준비 용품

Imidacloprid+Validamycin+Monosultap,W.P. Validamycin aqueous solution Validamycin+Diniconazole,W.P. Validamine

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A 공급 업체

글로벌( 260)공급 업체
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Qingdao Trust Agri Chemical Co.,Ltd 		+8613573296305
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Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
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Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075
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Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
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CONIER CHEM AND PHARMA LIMITED 		+8618523575427
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SIMAGCHEM CORP 		+86-13806087780
 sale@simagchem.com China 17367 58
Longyan Tianhua Biological Technology Co., Ltd 		0086 18039857276 18039857276
 CHINA 2783 58

[1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A 관련 검색:

트리스(하이드록시메틸)니트로메탄 모넨신 [1S-(1α,4α,5β,6α)]-1,5,6-트리데옥시-4-o-β-D-글루코피라노실-5-(하이드록시메틸)-1-[[4,5,6-트리하이드록시-3-(하이드록시메틸)-2-사이클로헥센-1-일]아미노]-D-키로이노시톨; 발리다마이신 A Valienamine Valiolamine Dianemycin 1-sodium salt Validamine D-chiro-inositol N-(2-HEPTYL)CYCLOHEXYLAMINE CIS-2-METHYLAMINO-CYCLOHEXANOL VALIDAMYCIN D Validamycin E Validamycin+Tricycloazole+Triadimefon,W.P.(16%) Validamycin+Buprofenzin+Isoprocarb,W.P.(32%) 28% carbendazim-jingangmeisu flowable formulation Validamycin+Buprofenzin+Monosultap,W.P. Imidacloprid+Validamycin,W.P.(15%) Validamycin+Bisultap,aqueous solusion
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