N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
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N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide 속성
- 녹는점
- 122-124°C
- 끓는 점
- 528.1±50.0 °C(Predicted)
- 밀도
- 1.166±0.06 g/cm3(Predicted)
- 저장 조건
- Refrigerator
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 13.65±0.46(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
안전
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide C화학적 특성, 용도, 생산
개요
Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.화학적 성질
White Solid용도
As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide 준비 용품 및 원자재
원자재
준비 용품
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide 공급 업체
글로벌( 37)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
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HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
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TargetMol Chemicals Inc. | +1-781-999-5354 |
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market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
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J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 |
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Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 |
info@tsbiochem.com | China | 8073 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 |
China | 4287 | 55 | |
Alfa Chemistry | 1-516-6625404 |
support@alfa-chemistry.com | United States | 9171 | 60 |