HMGB1 Monoclonal Antibody (Clone IMG19N10B7) C화학적 특성, 용도, 생산
개요
High Mobility Group Protein B
1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-
binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-
associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-
hemorrhage
via the activation of the Toll-
like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-
induced arthritis, and ischemia-
reperfusion induced tissue injury.
HMGB1 Monoclonal Antibody (Clone IMG19N10B7) 준비 용품 및 원자재
원자재
준비 용품
