2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
|
|
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 속성
- 녹는점
- 103 °C
- 끓는 점
- 438.3±40.0 °C(Predicted)
- 밀도
- 1.388
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- DMSO(약간 용해됨, 가열됨), 헥산(약간 용해됨,가열됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- InChI
- InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
- InChIKey
- VLRIERSBZHUCOW-UHFFFAOYSA-N
- SMILES
- C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2934999090 |
---|
그림문자(GHS): | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
|
||||||||||||||||||||||||||||
예방조치문구: |
|
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene C화학적 특성, 용도, 생산
Synthesis
prepares 2-(4-fluorophenyl) thiophene III:Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.
Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65~7.54(m,2H),7.33~7.22(m,2H),7.14~7.03(m,3H).Gc-Ms:178.1.
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 준비 용품 및 원자재
원자재
준비 용품
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 공급 업체
글로벌( 400)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12460 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20314 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16208 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21671 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 관련 검색:
5-bromo-2-chloro-4’-ethoxydiphenylmethane
(R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
4-(5-broMo-2-chlorobenzyl)phenol
2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE
5-Bromo-2-methylbenzoic acid
D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI)
(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
5-Bromo-2-methylbenzoyl chloride
5-Iodo-2-methylbenzoic acid
Canagliflozin heMihydrate
LIPOPHILIC SEPHADEX
2-(4-Fluorophenyl)-thiophene
BCP19353
Canagliflozin
5-Bromo-2-chlorobenzoic acid
(5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone