Vortioxetine hydrobromide
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Vortioxetine hydrobromide 속성
- 녹는점
- >223°C (dec.)
- 저장 조건
- Refrigerator
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 페일베이지부터 라이트베이지까지
- InChI
- InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
- InChIKey
- VNGRUFUIHGGOOM-UHFFFAOYSA-N
- SMILES
- S(C1C=CC(C)=CC=1C)C1C=CC=CC=1N1CCNCC1.Br
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 29339900 |
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Vortioxetine hydrobromide C화학적 특성, 용도, 생산
용도
Vortioxetine Hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).정의
ChEBI: Vortioxetine hydrobromide is a hydrobromide obtained by combining vortioxetine with one molar equivalent of hydrobromic acid. Used for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic antagonist and a serotonergic agonist. It contains a vortioxetine(1+).Synthesis
As the picture 2 showed, we have developed a new and practical synthetic route to vortioxetine hydrobromide on a hectogram scale. Adopting commercially available materials, through simple and traditional steps, including nucleophilic substitution, catalytic hydrogenation, and cyclization of the piperazine ring, gave the final product in 63.2% yield over three steps and with 99.3% purity (HPLC). Purification methods for the intermediates involved in the route are also given.![Synthesis_960203-27-4](https://img.chemicalbook.com/NewsImg/2022-01-07/2022177788995899.gif)
Pic.3 A new synthetic route to vortioxetine hydrobromide
Solubility in water
Vortioxetine hydrobromide is slightly soluble in water; at ambient temperature solubility is equivalent to approximately 1.3 mg base/mL, pH being 5.5 in the saturated solution.Mode of action
Vortioxetine Hydrobromide is a hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine.Vortioxetine hydrobromide 준비 용품 및 원자재
원자재
2,4-Dimethylbenzenethiol
보티옥세틴
2-피페라진-1-YL-페닐아민
2-((2,4-디메틸페닐)티오)페닐라민
1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene
비스(2-브로모에틸)암모늄브로마이드
4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester
1-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine Hydrochloride
4-IODO-M-XYLENE
2-BROMOTHIOPHENOL
준비 용품
Vortioxetine hydrobromide 공급 업체
글로벌( 363)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Seasons Biotechnology Co., Ltd. | +86-0576-89232655 +86-13566878689 |
info@seasonsbio.com | China | 47 | 58 |
Shandong Risen-Sun Pharmaceutical Co., Ltd | +86-15552509998 +86-15621883869 |
liutf@jewim.com.cn | China | 251 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10977 | 58 |
Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 |
market@hopelife.cn | China | 71 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 153 | 58 |
Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 |
info@millionpharm.com | China | 200 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Vortioxetine hydrobromide 관련 검색:
Unii-4bmh7izt98
tadalafi
di(2,4-xylyl) disulphide
Vorapaxar Sulfate
Vortioxetine
Vortioxetine iMpurity
Wortoxime hydrobromide impurity F
Pazopanib
Selumetinib
Axitinib
Bexarotene
Dasatinib
Benztropine mesylate
1-[2-[(2,6-diMethylphenyl)thio]phenyl]- Piperazine
Vortioxetine Impurity 34
Vortioxetine Impurity 25
Wortoxime hydrobromide impurity A
Wortoxime Hydrobromide Impurity C