2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 속성
- 끓는 점
- 403.0±45.0 °C(Predicted)
- 밀도
- 1.41±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- 12.88±0.50(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 신호 어: | Warning | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile C화학적 특성, 용도, 생산
개요
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is an important pharmaceutical intermediate. It can be used in the preparation of vorexanol fumarate and vonoprazan, and can also be used as a chemical raw material for the synthesis of other organic compounds.용도
2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.Synthesis
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is synthesised using 2-[2-(2-fluorophenyl)-2-oxoethyl]malononitrile as raw material by chemical reaction. The specific synthesis steps are as follows:2 g of the intermediate III-1 was dissolved in 40 ml of a solution of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature overnight. After the reaction is completed, the solvent is distilled off under reduced pressure to give the compound of 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile, 2.1 g of a white solid with a yield of 96%.
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 준비 용품 및 원자재
원자재
준비 용품
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 공급 업체
글로벌( 134)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18751 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14332 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
| Shanghai Jinghao Pharmaceutical Co.,Ltd | +86-21-68900963 |
sales@jinghaopharma.com | CHINA | 153 | 58 |
| CE Pharm Co.,Ltd | +86 13816833708 |
binbin.lin@cepharm.cn | CHINA | 52 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1319 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 |
marketing1@neostarunited.com | China | 8838 | 58 |
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 관련 검색:
Vonoprazan Fumarate impurity
(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol
4-Pyridinesulphonic acid
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
PYRIDINE-4-SULFONYL CHLORIDE
PYRIDINE-2-SULFONIC ACID
3-N,N-dimethylsulfamoylpyridine
1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester
5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile
1-(5-(2-fluorophenyl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl)-N- methylmethanamine fumarate
5-chloropyridine-3-sulfonyl chloride
1-methylpyridin-1-ium-4-sulfonate
1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-
(Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide