APOLIPOPROTEIN E, ISOFORM E3, HUMAN, RECOMBINANT 구조식 이미지
카스 번호:
상품명:
APOLIPOPROTEIN E, ISOFORM E3, HUMAN, RECOMBINANT
동의어(영문):
Apo E3;RHAPO E3;HUMAN APOE3;APO-E3, HUMAN;APOLIPOPROTEIN E3;APO-E3, HUMAN R-DNA;HUMAN APOLIPOPROTEIN E3;APOLIPOPROTEIN E, HUMAN;APOLIPOPROTEIN E3 HUMAN;APOLIPOPROTEIN E-III, HUMAN
APOLIPOPROTEIN E, ISOFORM E3, HUMAN, RECOMBINANT C화학적 특성, 용도, 생산
용도
Human ApoE has been used to study the role of apoE in the activity of LNP (lipid nanoparticles) in order to determine if ApoE has a role to play in the delivery of siRNA to hepatocytes.
일반 설명
Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 299 amino acid residues. The recombinant ApoE3 was manufactured using animal origin free technology.
Biochem/physiol Actions
ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Apart from participating in the metabolism of plasma lipoproteins, apo-E also interacts with several proteoglycans, such as heparin. The interaction of lipoproteins with proteoglycans in the walls of arteries has been associated with cholesterol deposition linked to atherosclerosis. It is found to be a constituent of several lipoproteins and serves as a ligand for the LDL (low density lipoprotein) receptor, thereby regulating cholesterol and triglyceride homeostasis.
APOLIPOPROTEIN E, ISOFORM E3, HUMAN, RECOMBINANT 준비 용품 및 원자재
원자재
준비 용품
APOLIPOPROTEIN E, ISOFORM E3, HUMAN, RECOMBINANT 공급 업체
