LD50 orally in rats, mice: 365, 1151 mg/kg; LD50 dermally in rats: >2000 mg/kg; LD50 by inhalation in rabbits: >5 mg/l; LC50(96 hr) in rainbow trout, bluegill sunfish (mg/l): 1.7, 3.1 (Pepin)
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H302
삼키면 유해함
급성 독성 물질 - 경구
구분 4
경고
P264, P270, P301+P312, P330, P501
H400
수생생물에 매우 유독함
수생 환경유해성 물질 - 급성
구분 1
경고
P273, P391, P501
예방조치문구:
P273
환경으로 배출하지 마시오.
BROMUCONAZOLE C화학적 특성, 용도, 생산
용도
Bromuconazole is used on winter wheat and barley for the control
of foliar mildews, rusts and other diseases.
정의
ChEBI: A member of the class of oxolanes carrying 1,2,4-triazol-ylmethyl and 2,4-dichlorophenyl substituents at position 2 as well as a bromo substituent at position 4. A foliar applied conazole fungicide for a range of crops including cereals, fruit, vegetables
and vines.
신진 대사 경로
Bromuconazole is a relatively stable compound which is not readily
hydrolysed, is quite persistent in soil and is subject to relatively slow
photodegradation. It is metabolised in plants but the parent compound
tends to be the major residue. However, bromuconazole is almost completely
metabolised in animals and birds (chickens) and its metabolites
are rapidly eliminated.
As with many other triazole fungicides, metabolism is very complex.
Bromuconazole exists in four forms (two diastereoisomeric pairs). There
are numerous sites available for biotransformation (lack of regioselectivity)
and there is also a lack of stereoselectivity at most sites. For example,
there are also four forms of metabolite 5 (4-hydroxybromuconazole) (two
diastereoisomeric pairs as with bromuconazole itself). Oxidation of
secondary alcohols to ketones and the thiolation of certain sites further
complicate the picture. Thiolation presumably occurs via the involvement
of glutathione but mercapturic acid conjugates (N-acetylcysteines)
do not appear to have been isolated.
Bromuconazole has been the subject of an evaluation by the Pesticide
Safety Directorate of UK MAFF. All of the information presented below is
derived from this source (PSD, 1996). All reported radiolabelled studies
were conducted using [14C-phenyl]bromuconazole.
