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trilaciclib

trilaciclib 구조식 이미지

카스 번호:: 1374743-00-6

상품명:: trilaciclib

동의어(영문):: Trilaciclib;Trilaciclib (G1T28);2'-[4-(4-methylpiperazin-1-yl)anilino]-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one;2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one;2'-((5-(4-methylpiperazin-1-yl) yridine-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one;Spiro[cyclohexane-1,9'(6'H)-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one, 7',8'-dihydro-2'-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-

CBNumber:: CB73353991

분자식:: C24H30N8O

포뮬러 무게:: 446.55

MOL 파일:: 1374743-00-6.mol

속성

안전

용도

공급 업체 71

trilaciclib 속성

밀도: 1.46±0.1 g/cm3(Predicted)

용해도: H2O:15.0(Max Conc. mg/mL);33.59(Max Conc. mM)

산도 계수 (pKa): 13.33±0.20(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: White to yellow

안전

trilaciclib C화학적 특성, 용도, 생산

용도

Trilaciclib is indicated to reduce the frequency of chemotherapy-induced bone marrow suppression in adults receiving certain types of chemotherapy for extensive-stage (when the cancer has spread beyond the lungs) small cell lung cancer.

상표명

Cosela^TM

Synthesis

The synthesis of trilaciclib is as follows:
Intermediate 2 (21.1 g, 70 mmol) and 1-methyl-4-(6-aminopyridin-3-yl)piperazine (13.4 g, 70 mmol) were added to a 100 mL vacuum tube and reacted at 230° C. for 3 h.After the reaction, 300 mL of ethyl acetate was added, washed with water (120 mL) and saturated brine (120 mL) successively, dried with anhydrous sodium sulfate and filtered, the obtained solution was evaporated under reduced pressure to remove the solvent, and the obtained residue was recrystallized with ethanol, 27.5 g of Trilaciclib was obtained with a purity of 99% and a yield of 88%.
synthesis of trilaciclib.png

저장

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

trilaciclib 준비 용품 및 원자재

원자재

준비 용품

trilaciclib 공급 업체

글로벌( 71)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10312	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7513	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14278	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Shanghai Huici Pharmaceutical Technology Co., LTD	+8618917134367	lixing@pharmahuici.com	China	133	58
Shanghai Huici Pharmaceutical Technology Co., LTD	+8618917134367	lixing@pharmahuici.com	China	133	58

trilaciclib 관련 검색:

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