BGC 20-1531 (hydrochloride)

BGC 20-1531 (hydrochloride) C화학적 특성, 용도, 생산

개요

BGC 20-1531 is a potent and selective antagonist of the prostaglandin E₂ (PGE₂; ) receptor subtype 4 (EP₄) with K_i values of 11.7, >10,000, and >10,000 nM for EP₄, EP₂, and EP₃, respectively. It is selective for EP₄, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE₂-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP₄ receptors. It also reverses PGE₂-induced vasorelaxation (K_b = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE₂-induced increases in carotid blood flow and decreases in carotid resistance with an ID₅₀ value of 5 mg/kg in dogs.

BGC 20-1531 (hydrochloride) 준비 용품 및 원자재

원자재

준비 용품

BGC 20-1531 (hydrochloride) 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30254	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Shanghai Luofa Biochemical Technology Co., Ltd.	021-51111890 15317326293	sales@molnova.com	China	4196	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58