BMS-986165
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BMS-986165 속성
- 저장 조건
- Store at -20°C
- 용해도
- DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- 물리적 상태
- 결정성 고체
- 색상
- Off-white to light yellow
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Danger | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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BMS-986165 C화학적 특성, 용도, 생산
일반 설명
Deucravacitinib, a highly selective allosteric TYK2 inhibitor, received its first approval from the FDA in 2022 for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy protein and lipid kinases and pseudokinases with the exception of BMPR2 (IC50 = 193 nM) and JAK1 JH2 pseudokinase domain (IC50 = 1 nM). Despite its potent affinity for JAK1 JH2, deucravacitinib elicited low functional activity in a JAK1/JAK3-dependent IL-2 stimulated cellular assay. BMS-986202 displays >10,000-fold selectivity for TYK2 JH2 over a diverse panel of 273 kinases and pseudokinases that include JAK family members. Like deucravacitinib, its high binding affinity to JAK1 JH2 (IC50 = 7.8 nM) did not translate to functional activity in the cellular assay.BMS-986165 준비 용품 및 원자재
원자재
2-Methoxy-3-nitrobenzamide
BMS-986165 Related Compound 6
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
3-(2-methoxy-3-nitrophenyl)-1-methyl-1H-1,2,4-triazole
3-(2-methoxy-3-nitrophenyl)-1H-1,2,4-triazole
메틸-2-메톡시-3-니트로벤조에이트
메틸-D3-아민염산염
에틸4,6-디히드록시피리다진-3-카르복실레이트
에틸4,6-DICHLOROPYRIDAZINE-3-CARBOXYLATE
METHYL 2-HYDROXY-3-NITROBENZOATE
CYCLOPROPANECARBOXAMIDE
3-Nitrosalicylic acid
준비 용품
BMS-986165 공급 업체
글로벌( 171)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 |
sales@anbuchem.com | China | 3000 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 74 | 58 |
Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 |
info@pharmachemm.com | China | 225 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 25604 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
Hangzhou Proserre Chemical Co.,Ltd. | +86-571-86088112 |
info@proserre.com | China | 1077 | 58 |