Histone H3 Polyclonal Antibody

Histone H3 Polyclonal Antibody C화학적 특성, 용도, 생산

개요

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination. Histone H3 PTMs function as epigenetic regulators of gene transcription by affecting chromatin structure and providing binding sites for many transcription factors, thus regulating several cellular functions including gene expression, cell cycle, and DNA replication and repair. Differential methylation of histone H3 at various lysine residues is catalyzed by SET domain-containing methyltransferases and marks sites of transcriptional activation or repression. Citrullination of histone H3 by protein arginine deiminase 4 (PAD4; Item Nos. 10500 | 25915 | 28910) or PAD2 induces the release of neutrophil extracellular traps (NETs), a network of decondensed DNA and intracellular proteins secreted by neutrophils as a pathogen defense mechanism. Histone H3 mutations have been found in patients with diffuse intrinsic pontine glioma, leukemia, or chondroblastoma. Cayman''s Histone H3 Polyclonal Antibody can be used for ELISA, flow cytometry (FC), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes histone H3 at 15.5 kDa from human samples.

Histone H3 Polyclonal Antibody 준비 용품 및 원자재

원자재

준비 용품

Histone H3 Polyclonal Antibody 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Rhenbo (Shanghai) Biochemical Technology Co., Ltd.	--		CHINA	6334	58
Hangzhou Lianke Biotechnology Co., Ltd.	--		CHINA	6349	58
Shanghai Bangyi Biological Technology Co., Ltd.	--		CHINA	5682	58
Kelu (Wuhan) Biotechnology Co., Ltd.	--		CHINA	5344	58
Shanghai Mengze Biotechnology Co., Ltd.	--	luxionggang@126.com	CHINA	6393	58
Beijing Bomais Technology Development Co., Ltd.	--	15210716102@139.com	CHINA	6573	58
Suzhou Far East Puhui Biotechnology Co., Ltd.	--	2810475392@qq.com	CHINA	5225	58
Nanjing Laifusai Biological Technology Co., Ltd.	--	info@lifescimall.com	CHINA	6638	58
Thermo Fisher Scientific	--	sales.china@thermofisher.com	CHINA	5672	58
Cayman Chemical Company	--	cayman@caymanchem.com	United States	6618	81