메틸에페드린
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메틸에페드린 속성
- 녹는점
- 86-88 °C(lit.)
- 끓는 점
- 311.8°C (rough estimate)
- 밀도
- 1.0020 (rough estimate)
- 굴절률
- 1.5065 (estimate)
- 인화점
- 9℃
- 저장 조건
- Refrigerator (+4°C)
- 산도 계수 (pKa)
- pKa 9.257(H2O,t =25,I=0.00) (Uncertain)
- 물리적 상태
- 가루
- 감도
- Moisture Sensitive
- Merck
- 14,6068
- CAS 데이터베이스
- 552-79-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,T,F | ||
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위험 카페고리 넘버 | 36/37/38-39/23/24/25-23/24/25-11 | ||
안전지침서 | 26-36-45-36/37-16-7 | ||
유엔번호(UN No.) | 1544 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 3 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
기존화학 물질 | KE-11145 |
그림문자(GHS): | ||||||||||||||||||||||||||||||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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메틸에페드린 C화학적 특성, 용도, 생산
개요
The Chinese plant 'Ma-Huang' contains this alkaloid, first isolated by Smith. According to Read, the name 'Ma-Huang' is the name for various Ephedra species but the material principally used in China is E. sinica Stapf. (Syn. E. j7ava Porter Smith, E. Mahuang Liu). It has subsequently been discovered in European species, notably E. helvetica C. A. Meyer and E. distachya Linn. The alkaloid crystallizes in stout, colourless needles and has [α]D - 29.2° (MeOH). It yields several crystalline salts and derivatives: hydrochloride, m.p. 188-9°C; [α]20D - 29.8° (H20); oxalate, m.p. 187°C; aurichloride, m.p. 128-9°C; picrate, m.p. 144°C and the methiodide, m.p. 212-3°C; [α]D - 21.8° (H20).화학적 성질
White crystals or adhering crystalline powder용도
adrenergic agonist, analepticPurification Methods
N-Methylephedrine has been recrystallised from Et2O, pet ether, of aqueous EtOH or aqueous MeOH and has been distilled under reduced pressure. [Smith J Chem Soc 2056 1927, Tanaka & Sugawa Yakugaku Zasshi (J Pharm Soc Japan) 72 1548 1952 (Chem Abstr 47 8682 1953), Takamatsu Yakugaku Zasshi (J Pharm Soc Japan) 76 1227 1956, Chem Abstr 51 4304 1957.] The hydrochloride has m 192-193o and [] D (c 5,H2O)[Prelog & Hüfliger Helv Chim Acta 33 2021 1950].20+30o [Beilstein 13 IV 1884.]참고 문헌
Smith., J. Chern. Soc., 2056 (1927)Smith., ibid, 51 (1928)
Smith., ibid, 2755 (1929)
Wolfes., Arch. Pharrn., 268,327 (1930)
Preparation:
Nagai., J. Pharrn. Soc., Japan, No. 120, 109 (1892)
Nagai, Kanao., ibid, 48, 145 (1928)
메틸에페드린 준비 용품 및 원자재
원자재
준비 용품
메틸에페드린 관련 검색:
에페드린 N-메틸에페드린 비쿠쿨린
Trecadrine
(1S,2R)-N-TOSYLEPHEDRINE
(1R,2S)-2-DI-N-BUTYLAMINO-1-PHENYL-1-PROPANOL
tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
(S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE
(-)-BETA-HYDRASTINE
Ipenoxazone
(-)-N-METHYLEPHEDRINE
(-)-BICUCULLINE METHOBROMIDE
(-)-N-DODECYL-N-METHYLEPHEDRINIUM BROMIDE
dl-Methylephedrine HCl ,dl-methylephedrine hydrochloride
L-N-METHYLEPHEDRINE HYDROCHLORIDE,METHYLEPHEDRINE HCL,(IR,2S)-I-N-Methylephedrine HCL
(+)-N-METHYLEPHEDRINE
1-Phenyl-1-propanol