CYCLOPAMINE
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CYCLOPAMINE 속성
- 녹는점
- 236-238°C
- 끓는 점
- 531.29°C (rough estimate)
- 밀도
- 1.0274 (rough estimate)
- 굴절률
- 1.6400 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- DMSO: 용해될 수 있다
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 15.05±0.70(Predicted)
- 색상
- 하얀색
- 안정성
- -20°C의 냉장고에 보관하세요
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
안전지침서 | 22-24/25 | ||
WGK 독일 | 3 | ||
RTECS 번호 | GY0750000 | ||
HS 번호 | 29349990 | ||
유해 물질 데이터 | 4449-51-8(Hazardous Substances Data) |
CYCLOPAMINE C화학적 특성, 용도, 생산
개요
Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-화학적 성질
White Crystalline Solid용도
Has antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 Solubility: 1mg dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.) Solubility: 4mg dissolves in 1ml 95% Ethanol생물학적 활성
Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anti-cancer and teratogenic in vivo . Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment.Anticancer Research
Cyclopamine is a natural compound that inhibits the Hedgehog signaling pathway.Cyclopamine targets Hedgehog by specifically hindering SMO activation.Cyclopamine therapy of murine medulloblastoma resulted in the inhibition ofproliferation, induction of neuronal differentiation, effective depletion of CSCs, andreduction of tumor burden in a mouse tumor allograft. Cyclopamine is effective inkilling of pancreatic, breast, and multiple myeloma CSCs. Cyclopamine incombination with gemcitabine inhibits metastatic spread and reduces primary tumorburden in pancreatic orthotopic xenografts. Mammosphere formation in breastcarcinoma and SC proliferation in multiple myeloma can be reduced by cyclopamine(Kawasaki et al. 2008). The HH ligand activation requires cholesterol at theircarboxyl ends, and 22-OH-cholesterol and 20-OH-cholesterol are reported toincrease the HH target gene expression, and this hypothesis of cholesterol-dependentHH signal transduction is investigated in M2-10B4 pluripotent mesenchymal stemcells. The mechanism underlying the positive regulation of HH signaling by theseoxidative species of cholesterol is not clear. However, this oxidative status ofcholesterol is altered by the endogenous ROS. Hence, the bioactive food componentsthat control the ROS levels can be important in regulating self-renewal and HHpathways (Kim et al. 2012). Cholecalciferol (vitamin D3, an isoform of vitamin D)is reported to be HH antagonist in vitro but not in vivo. Binding of cholecalciferol toSMO receptors results in the reduction of HH signaling in MDAMB231 andC3H/10 T1/2 fibroblast cells. 1 μM vitamin D3 shows more potent SMO inhibitoryaction than 10 μM cyclopamine in PTCH1-transfected C3H/10 T1/2 cells (Kimet al. 2012). Curcumin interferes with the Gli1 mRNA or Gli reporter activity andinhibits HH signaling in transgenic mouse prostate adenocarcinoma cells (Kimet al. 2012).CYCLOPAMINE 준비 용품 및 원자재
원자재
준비 용품
CYCLOPAMINE 공급 업체
글로벌( 237)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 |
sales@zhswyy.com | China | 301 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3777 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
CYCLOPAMINE 관련 검색:
모노크로탈린
Glycitin
GANT61
MK-2206 2HCl
Vismodegib (GDC-0449)
Dasatinib
Purmorphamine
Ruxolitinib
CYCLOPAMINE
DESPIRO-CYCLOPAMINE
BODIPY CYCLOPAMINE
N-(2-AMINOETHYL) CYCLOPAMINE
CYCLOPAMINE-KAAD,KAAD-CYCLOPAMINE,3-KETO-N-(AMINOETHYL-AMINOCAPROYL-DIHYDROCINNAMOYL)CYCLOPAMINE
3-HYDROXY-N-AMINOETHYL-N'-AMINOCAPROYLDIHYDROCINNAMOYL CYCLOPAMINE
CY-3-CYCLOPAMINE, POTASSIUM SALT,CYANINE-3 CYCLOPAMINE, POTASSIUM SALT
FLUORESCEINYL CYCLOPAMINE
3-KETO-N-AMINOETHYL-N'-AMINOCAPROYLDIHYDROCINNAMOYL CYCLOPAMINE
Cyclopamine hedgehog