LD50 in mice (mg/kg): 600 i.p.; 300 i.v. (Thiemann, Murthy)
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H302
삼키면 유해함
급성 독성 물질 - 경구
구분 4
경고
P264, P270, P301+P312, P330, P501
예방조치문구:
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312
삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330
입을 씻어내시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
Alanosine C화학적 특성, 용도, 생산
화학적 성질
Crystalline Powder
용도
Antibiotic substance from the fermentation of Streptomyces alanosinicus. The first natural product found to have a N-nitrosohydroxylamino group on an aliphatic chain. An experimental insect reproduction inhibitor
효소 저해제
This antibiotic and aspartate/asparagine analogue (FW = 149.11 g/mol; CAS 5854-93-3), also named L-2-amino-3-(N-hydroxy-N-nitrosoamino) propionic acid, isolated from fermentation broths of Streptomyces alanosinicus, inhibits adenylosuccinate synthetase, disrupting de novo synthesis of AMP in both malignant and normal cells. That alanosine inhibits the adenylosuccinate synthetase reaction, the first step in the conversion of IMP to AMP, is evidenced by the accumulation of IMP, but not adenylosuccinate, in treated cells. L-Alanosine’s action is potentiated in methylthioadenosine phosphorylase (MTAP) deficiency. Clinical use is limited by its toxicity. At a concentration as low as 2.7 μM, L-alanosine completely inhibits the incorporation of hypoxanthine into adenosine triphosphate by cultured Novikoff rat hepatoma cells. A related agent, L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (or alanosyl-AICOR) has been synthesized enzymatically using 4-(N-succino)- 5-aminoimidazole-4-carboxamide ribonucleotide (or SAICAR) synthetase in conjunction with 5-aminoimidazole-4-carboxylic acid ribonucleotide and alanosine. Alanosyl-AICOR is not a substrate of adenylosuccinate lyase from rat skeletal muscle, but it was an apparent competitive inhibitor in both reactions catalyzed by the enzyme.
