염산 히드록실아민
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염산 히드록실아민 속성
- 녹는점
- 155-157 °C (dec.)(lit.)
- 밀도
- 1.67 g/mL at 25 °C(lit.)
- 증기압
- 0.054 Pa (50 °C)
- 저장 조건
- Store at +15°C to +25°C.
- 용해도
- 470g/L
- 물리적 상태
- 액체
- 색상
- 흰색에서 황백색까지
- 수소이온지수(pH)
- 2.5-3.5 (25℃, 50mg/mL in H2O)
- 수용성
- 560g/L(20℃)
- 감도
- Hygroscopic
- Merck
- 14,4828
- BRN
- 3539763
- 안정성
- 피해야 할 물질에는 강한 산화제가 포함됩니다. 115C 이상으로 가열하면 폭발할 수 있습니다. 65C 이상에서 보관하지 마십시오. 습기와 공기에 민감합니다.
- InChIKey
- WTDHULULXKLSOZ-UHFFFAOYSA-N
- LogP
- -0.810 (est)
- CAS 데이터베이스
- 5470-11-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,N,E | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/38-43-48/22-50-40-21/22-2 | ||
| 안전지침서 | 22-24-37-61-36/37 | ||
| 유엔번호(UN No.) | UN 2923 8/PG 2 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | NC3675000 | ||
| F 고인화성물질 | 21 | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 28251000 | ||
| 독성 | LD50 orally in mice: 408 mg/kg (Riemann) | ||
| 기존화학 물질 | KE-20602 | ||
| 유해화학물질 필터링 | 97-1-411 | ||
| 함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 히드록실아민과 그 염류 및 그 중 하나를 1% 이상 함유한 혼합물 |
염산 히드록실아민 C화학적 특성, 용도, 생산
물성
히드 록실 아민 히드로 클로라이드는 무색의 결정 성의 조해성의 백색 화학 물질로 주로 옥심을 제조하기 위해 유기 합성에 사용되는 환원제 및 이미징 제로 사용됩니다. 항암제 (hydroxyurea), 설파 미드 (sulfamethoxifen) 및 살충제 (methomyl)의 합성 원료로 사용됩니다.물성
피해야 할 물질은 강한 산화제를 포함합니다. 115 ℃ 이상으로 가열하면 폭발의 위험이 있습니다. 65C 이상으로 보관하지 마십시오. 습기와 공기에 민감합니다.용도
이 제품은 항암제 (hydroxyurea), sulfamethylamine (sulfamide) 및 살충제 (methomyl)의 합성 원료뿐만 아니라 유기 합성에서 옥심의 제조에 사용되는 환원제 및 이미징 제로 주로 사용됩니다. 그것은 전기 분석에서 depolarization 에이전트 및 합성 고무 산업에서 비 착색 단기 정지 에이전트로 사용됩니다. 제약 업계는 nenomine의 중간체로 사용됩니다. 합성 염료는 indirubin 중간체의 제조에 사용됩니다. 그리스 산업은 지방산과 비누의 산화 방지제로 사용됩니다. 분석 화학은 포름 알데히드, 푸르 푸랄, 녹나무 및 포도당의 분석에 사용됩니다. 전기 화학 분석에서의 탈분극. 또한 철과 강철의 마그네슘 측정, 설 폰산과 지방산의 미량 분석, 알데히드와 케톤의 측정 및 탈 극성 화제로 사용됩니다. 또한, 컬러 필름 현상 등에도 사용됩니다.개요
Hydroxylamine hydrochloride is a reducing agent that is routinely used for the deacetylation of SATA to form free sulfhydryls (Figure 1), for cleavage of protein cross‐linkers that contain carbonyl groups (i.e. EGS) and for mutagenesis of plasmid DNA.
Hydroxylamine converts aldehydes and ketones (carbonyls) to their oxime derivative in weak bases, therefore cross‐linkers and other compounds with carbonyl groups are cleavable with Hydroxylamine hydrochloride.
SATA and SATP are modification reagents that add a sulfhydryl group to primary amines on biomolecules. The initial modification results in the addition of an acetyl‐protected sulfur enabling storage of the biomolecule. To generate a free sulfhydryl the biomolecule is treated with hydroxylamine to remove the protecting acetyl group (see figure).
EGS and sulfo‐EGS are homobifunctional, succinimidyl ester, amine reactive crosslinkers that are resistant to cleavage by denaturants used in SDS‐PAGE conditions, but may be cleaved with hydroxylamine.
화학적 성질
Hydroxylamine Hydrochloride(NH2OH.HCl) is an inorganic compound that is the hydrochloric acid salt of hydroxylamine. It is highly hygroscopic and decomposes when exposed to dampness above 151℃. This compound is primarily used as a reducing agent and imaging agent and is instrumental in the preparation of oximes in organic synthesis. It can convert aldehydes and ketones to oximes and acid chlorides to hydroxamic acids. However, This product is highly toxic and irritating to the skin.물리적 성질
It is a colorless monoclinic crystal that is hygroscopic and decomposes slowly in moist air. It has a density of 1.67 g/cm3 at a temperature of 17°C and melts at 151°C with decomposition. It is highly soluble in water, with a solubility of 84g/100g at 20°C, and is also soluble in lower alcohols and glycols. A 0.1 molar solution of this substance has a pH of 3.4.용도
Hydroxylamine hydrochloride is a monomoamine oxidase inhibitor. It is used to prepare oximes and hydroxmic acids in organic synthesis. It acts as a copolymerization inhibitor. It can be used to remove bromine and polybromide from a solution during extraction of lignin from lignocellulosic biomass. It is key starting material for the preparation of pharmaceuticals and agrochemicals. It plays a vital role in rubber and plastic industries as an antioxidant, a vulcanization accelerator and a radical scavenger. It is also used as a color stabilizer and emulsion additive in color films.정의
ChEBI: Hydroxylamine hydrochloride is an organic molecular entity. It is a colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.제조 방법
Hydroxylamine hydrochloride is prepared by electrolytic reduction of ammonium chloride. Or by the action of nitromethane with hydrochloric acid and water to obtain hydroxylamine hydrochloride.Biotechnological Applications
Hydroxylamine hydrochloride is a strong reducing agent that is useful in biochemical crosslinking applications, including the deacetylation of SATA and chemical cleavage of EGS and Sulfo-EGS. Hydroxylamine converts carbonyl compounds (aldehydes and ketones) to their oxime derivatives in the presence of a weak base. Therefore, crosslinkers and other compounds that contain a carbonyl within their structure are cleavable with hydroxylamine?HCl.MAN0011201_HydroxylamineHCl_UG.pdf
일반 설명
Hydroxylamine hydrochloride appears as colorless or off-white crystalline solid. pH (0.1 molar aqueous solution) 3.4. pH (0.2 molar aqueous solution) 3.2. (NTP, 1992)공기와 물의 반응
Hygroscopic. Sensitive to prolonged exposure to air. Water soluble. Reacts slowly with water.반응 프로필
A powerful reducing agent. Reacts with bases and oxidizing agents.위험도
Toxic by ingestion, strong irritant to tissue.화재위험
Flash point data for Hydroxylamine hydrochloride are not available; however, Hydroxylamine hydrochloride is probably combustible.색상 색인 번호
Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.Purification Methods
Crystallise the salt from aqueous75% ethanol or boiling methanol, and dry it under vacuum over CaSO4 or P2O5. It has also been dissolved in a minimum of water and saturated with HCl; after three such crystallisations, it is dried under a vacuum over CaCl2 and NaOH. Its solubility at 20o is 85% in H2O, 6% in EtOH and 12% in MeOH. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1941.]염산 히드록실아민 준비 용품 및 원자재
원자재
준비 용품
2-CHLOROBENZALOXIME
Pyrazole-1,3-dimethyl-5-phenoxy-4-carboxaldehyde oxime
Methyl 3-amino-4-methylthiophene-2-carboxylate
4-(METHYLTHIO)BENZYLAMINE
4-AMINO-1,2,5-OXADIAZOLE-3-CARBONITRILE
2-피리딜아미독심
5-AMINOISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
ETHYL 5-METHYLISOXAZOLE-3-CARBOXYLATE
5 A-CHLORO-6 B,19-EPOXY-3 B -HYDROXY-5 A-ANDROSTAN-17-ONE
4-피리딜아미독심
5-Chloro-3,6-dihydroxy-5-androstan-17-one 3-acetate
ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE
3,4,5-Trimethoxybenzylamine
Epiandrosterone acetate
3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid
2-부타논 옥심
5-METHYL-4-ISOXAZOLESULFONYL CHLORIDE
NEMONAPRIDE
5-Methyl-3-phenylisoxazole
2,6-Dicyano-4-Nitroaniline
DIPHENYLGLYOXIME
6-AMINO-2-METHYL-2-HEPTANOL
3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
6-Bromoisatin
4-Aminotetrahydropyran hydrochloride
5-Methyl-3-phenylisoxazole-4-carbonyl chloride
3-METHYLTHIOPHENE-2-CARBONITRILE
(2,6-DIMETHYLPHENOXY)ACETOXIME
3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic acid
3-METHYL-5-PHENYLISOXAZOLE
Adrafinil
3-피리딜아미독심
Ethyl 5-methyl-3-phenylisoxazole-4-carboxylate
벤자마이드 옥심
2,3-DIMETHOXYBENZONITRILE
heptanal oxime
17-Ethinylandrost-5-ene-3,17-diol
N-Hydroxysulfosuccinimide sodium salt
3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID
2-AMINO-5,6-DICHLOROBENZOIC ACID
염산 히드록실아민 공급 업체
글로벌( 840)공급 업체
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