ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT

ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT 구조식 이미지
카스 번호:
상품명:
ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT
동의어(영문):
ANTI-PHOSPHO-CAM KINASE IIALPHA;ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT;CA2+/CALMODULIN KINASE II ALPHA-SUBUNIT-PHOSPHORYLATED (AB-2) MONOCLONAL ANTIBODY;Monoclonal Anti-phospho-CaM Kinase IIα (pThr286) antibody produced in mouse
CBNumber:
CB8163736
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT 속성

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ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT C화학적 특성, 용도, 생산

용도

Anti-phospho-CaM Kinase IIα (pThr286) antibody may be used in indirect immunofluorescence at a working dilution of 1:100 in rat hippocampal cells fixed with cold methanol. Detection by immunoblotting is possible at a working dilution of 1:1000.

일반 설명

Intracellular Calcium (Ca2+) acts as major secondary messenger that mediates signalling induced by hormones and neurotransmitters. Cellular responses to calcium are modulated by a family of Ca2+/Calmodulin dependent protein kinases. The members of this family include CaMK I, CAMK II and CAMK IV. These kinases mediate rapid, highly specific and reversible post-translational modification involving ATP. CaMK II is abundantly expressed in mammalian brain, with highest expression in neurons of hippocampus and cerebral cortex, and plays critical role in synaptic transmission, memory, learning and behaviour. CaMK II family has four members, CaMK IIα, CaMK IIβ, CaMK IIγ and CaMK IIδ. The CaMK IIα?and β?isoforms are predominantly expressed in the brain, localized mainly in the cytosol and postsynaptic densities (PSDs), whereas the CaMK IIγ and δ isoforms are expressed in all tissues. CaMK II is autophosphorylated at α-Thr286 residue in response to changes in the concentration of intracellular calcium. This may prolong physiological responses to temporary changes in Ca2+ concentrations. CaMK II regulates synaptic signalling by phosphorylating glutamate receptors in the neurons. A distinct CaMK II has also been implicated in the process of smooth muscle contraction by phosphorylation of myosin light chain kinase.
This product reacts with the recombinant and native rat phosphorylated CaMK II α subunit only (50 kDa). It does not cross-react with the non-phosphorylated α subunit or with the 60 kDa β subunit in either phosphorylation state.

ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT 준비 용품 및 원자재

원자재

준비 용품


ANTI-CAM KINASE II-PHOSPHORYLATED, ALPHA SUBUNIT 공급 업체

글로벌( 4)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Riedel-de Haen AG --
United States 6825 87
SIGMA-RBI --
Switzerland 6913 91
VWR International --
solutions@vwr.com United Kingdom 6554 82
ABR-Affinity BioReagents --
affinity@bioreagents.com United States 489 73

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