Dcp1 colocalizes with Dcp2 in distinct cytoplasmic foci along with other proteins involved in the 5′ to 3′ mRNA decay. These foci are termed PB (processing bodies) or DCP-bodies. Anti-DCP1A (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to a sequence at C-terminal of human DCP1A conjugated to KLH. Two distinct genes of human DCP1 were identified, DCP1A and DCP1B, which share ~70% homology in their N-terminal and ~30% homology in their full length.
Biochem/physiol Actions
Dcp1 cleaves the m7G mRNA cap in the 5′ to 3′ mRNA decay pathway, in association with Dcp2 and Hedls complex. Decapping is a critical and highly regulated step in the turnover of mRNA which involves decapping enzymes that hydrolyze the cap structure at the 5′ mRNA.
Anti-DCP1 Decapping enzyme 1, homolog A, Anti-Smad 4-interacting transcription factor, Anti-Smad 4-interacting transcriptional co-activator, Anti-SMAD4IP1, Anti-SMIF 준비 용품 및 원자재
원자재
준비 용품
Anti-DCP1 Decapping enzyme 1, homolog A, Anti-Smad 4-interacting transcription factor, Anti-Smad 4-interacting transcriptional co-activator, Anti-SMAD4IP1, Anti-SMIF 공급 업체