아리피프라졸
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아리피프라졸 속성
- 녹는점
- 139°C
- 끓는 점
- 646.2±55.0 °C(Predicted)
- 밀도
- 1.263±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 용해성5mg/mL, 투명(가온)
- 산도 계수 (pKa)
- 14.42±0.20(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- Merck
- 14,785
- BCS Class
- 2
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
- InChI
- InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
- InChIKey
- CEUORZQYGODEFX-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CCC1=O
- CAS 데이터베이스
- 129722-12-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 11-20/21/22-36 | ||
| 안전지침서 | 16-36/37 | ||
| 유엔번호(UN No.) | UN 1993C 3 / PGIII | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | VC8275950 | ||
| HS 번호 | 29349990 | ||
| 유해 물질 데이터 | 129722-12-9(Hazardous Substances Data) | ||
| 독성 | TDLo ivn-dog: 0.03 mg/kg/10M TXAPA9 173,120,2001 |
아리피프라졸 C화학적 특성, 용도, 생산
화학적 성질
Colourless Flake Crystalline Solid용도
A deuterated version of Aripiprazole, a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Please note that users have reported separation of this compound and aripiprazole under normal-phase and reverse-phase일반 설명
Aripiprazole (Abilify). The newest, longactingaripiprazole (an arylpiperazine quinolinone derivative),appears to be partial agonist of D2 receptors (i.e., itstimulates certain D2 receptors while blocking others dependingon their locations in the brain and the concentrationof drug). Bioavailability of aripiprazole is around 87%, with peak plasma concentration attained at 3 to 5 hours afterdosing. It is metabolized by dehydrogenation, oxidative hydroxylation, and N-dealkylation, largelymediated by hepatic CYPs 3A4 and 2D6.The diphenylbutylpiperidine class can be considered amodification of the fluorobutyrophenone class. Because oftheir high lipophilicity, the compounds are inherently longacting. Pimozide has been approved for antipsychotic use,and penfluridol has undergone clinical trials in the UnitedStates. Overall, side effects for the two compounds resemblethose produced by the fluorobutyrophenones.
위험도
A poison.Safety Profile
A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and Cl-.아리피프라졸 준비 용품 및 원자재
원자재
M-클로로아닐린
1,4-디브로모부탄
트리에틸아민
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Aripiprazole hydrochloride
2(1H)-Quinolinone, 3,4-dihydro-7-(2-propen-1-yloxy)-
3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone
3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone
1-(2,3-디클로로페닐)-피페라진염산염
준비 용품
아리피프라졸 공급 업체
글로벌( 674)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Protheragen-ING | +16313385890 |
info@protheragen-ing.com | United States | 3868 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12840 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 283 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 148 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 615 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
| Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 |
angelia@hbmojin.com | China | 1177 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 444 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
아리피프라졸 관련 검색:
(베타-하이드록시에틸)피페라진
OPC-14714
Aripiprazole N1-Oxide
Aripiprazole Dimer
Aripiprazole Related CoMpound B
Aripiprazole N4-Oxide
1-(2,6-dichlorophenyl)piperazine
Aripiprazole Metabolite
Aripiprazole iMpurity 2
2-Deschloro Aripiprazole
Aripiprazole Impurity 19
7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE
1,4-BIS[3,4-DIHYDRO-2(1H)-QUINOLINON-7-OXY]BUTANE
Aripiprazole iMpurity 3
3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone
N-(2,3-Dichloro-phenyl)-N'-[2-(2,3-dichloro-phenylamino)-ethyl]-ethane-1,2-diamine
N-(2-Chloro-ethyl)-N'-(2,3-dichloro-phenyl)-ethane-1,2-diamine
Aripiprazole N,N-Dioxide