Unii-0Bz5A00fqu

Unii-0Bz5A00fqu C화학적 특성, 용도, 생산

화학적 성질

Polacrilin potassium occurs as a cream-colored, odorless and tasteless, free-flowing powder. Aqueous dispersions have a bitter taste.

용도

Pharmaceutic aid (tablet disintegrant).

생산 방법

Polacrilin resin (Amberlite IRP-64) is prepared by the copolymerization of methacrylic acid with divinylbenzene (DVB). Polacrilin potassium (Amberlite IRP-88) is then produced by neutralizing this resin with potassium hydroxide.
Other resins are similarly produced by copolymerization between styrene and divinylbenzene (Amberlite IRP-69, Amberlite IRP-67, Amberlite IR-120, and Amberlite IRA-400). Phenolicbased polyamine condensates (Amberlite IRP-58) may also be produced.
The homogeneity of the resin structure depends on the purity, nature, and properties of the copolymers used as well as the controls and conditions employed during the polymerization reaction. The nature and degree of crosslinking have significant influence on the physicochemical properties of the resin matrix. The functional groups introduced on the matrix confer the property of ion exchange. Depending upon the acidity or basicity of the functional groups, strongly acidic to strongly basic types of ion-exchange resins may be produced.

Pharmaceutical Applications

Polacrilin potassium is a cation-exchange resin used in oral pharmaceutical formulations as a tablet disintegrant Concen-trations of 2–10% w/w have been used for this purpose, although 2% w/w of polacrilin potassium is usually sufficient. Other polacrilin ion-exchange resins have been used as excipients to stabilize drugs, to mask or modify the taste of drugs, and in the preparation of sustained-release dosage forms and drug carriers.
Polacrilin resins are also used in the analysis and manufacture of pharmaceuticals and food products.

Safety

Polacrilin potassium and other polacrilin resins are used in oral pharmaceutical formulations and are generally regarded as nontoxic and nonirritant materials. However, excessive ingestion of polacrilin resins may disturb the electrolyte balance of the body.

저장

Polacrilin potassium and other polacrilin resins are stable to light, air, and heat up to their maximum operation temperature. Excessive heating can cause thermal decomposition of the resins and may yield one or more oxides of carbon, nitrogen, sulfur, and/or amines.
Polacrilin resins should be stored in well-closed containers in a cool, dry place.

비 호환성

Incompatible with strong oxidizing agents, amines, particularly tertiary amines, and some other substances that interact with polacrilin resins.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in non-parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Unii-0Bz5A00fqu 준비 용품 및 원자재

원자재

준비 용품

Unii-0Bz5A00fqu 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973186 4009686088	3193328036@qq.com	China	18352	68

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