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(1S-cis)-밀나시프란염산염

(1S-cis)-밀나시프란염산염 구조식 이미지

카스 번호:: 175131-60-9

한글명:: (1S-cis)-밀나시프란염산염

동의어(한글):: (1S-cis)-밀나시프란염산염

상품명:: (1S-cis)-Milnacipran Hydrochloride

동의어(영문):: Levominaprine;L-Milnacipran HCl;Levomilnacipran HCl;F 2695 hydrochloride;Milnacipran (1S-cis);Sitafloxacin Impurity 70;Levomilnacipran HCl (F2695;L-Milnacipran Hydrochloride;LevoMilnacipran hydrochloride;(1S,2R)-Milnacipran hydrochloride

CBNumber:: CB82510923

분자식:: C15H23ClN2O

포뮬러 무게:: 282.81

MOL 파일:: 175131-60-9.mol

속성

안전

용도

공급 업체 135

(1S-cis)-밀나시프란염산염 속성

저장 조건: Store at -20°C

용해도: DMSO:57.0(Max Conc. mg/mL);201.55(Max Conc. mM)

물리적 상태: 결정성 고체

색상: White to off-white

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P321	(…) 처치를 하시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P362	오염된 의복을 벗고 세척 후에 재사용하기

NFPA 704

	0
2		0

(1S-cis)-밀나시프란염산염 C화학적 특성, 용도, 생산

개요

Levomilnacipran (Fetzima®) is a dual serotonin–norepinephrine reuptake inhibitor (SNRI) approved by the FDA in 2013 for the treatment of major depressive disorders (MDD). Levomilnacipran is the most active enantiomer of the racemate Milnacipran, which is currently used to treat pain associated with fibromyalgia. The drug was developed by Forest Laboratories and the Pierre Fabre group.

용도

The S-enatiomer of Milnacipran (M344600).

Synthesis

Reaction of phenylacetonitrile (100) and commercially available (R)-epichlorohydrin (101) with NaNH2 led to chloride displacement and intramolecular cyclopropanation, yielding lactone 102 after a one-pot nitrile hydrolysis and acid-promoted lactonization (75% yield over 3 steps). Lactone ring-opening with Et2NH¨CAlCl3 complex provided amido-alcohol 103, which was converted to its phthalimido derivative 104 by sequential treatment with thionyl chloride and potassium phthalimide in 80% over three steps. Finally, levomilnacipran hydrochloride (XIII) was obtained in >95% optical purity after phthalimide cleavage, HCl salt formation, and crystallization from HCl/i-PrOH/i-PrAc. This sequence represents a highly efficient route to levomilnacipran, requiring no isolation of intermediates, resulting in >40% overall yield, and allowing use of the same solvent solution (toluene) for all steps.

Synthesis_175131-60-9

(1S-cis)-밀나시프란염산염 준비 용품 및 원자재

원자재

준비 용품

(1S-cis)-밀나시프란염산염 공급 업체

글로벌( 135)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Jurong Coupling Biotechnology Co., Ltd.	13656108824	coupling278191416@hotmail.com	CHINA	184	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3095	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2994	58

(1S-cis)-밀나시프란염산염 관련 검색:

LEVOGLUCOSENONE Methyl D-(-)-4-hydroxy-phenylglycinate (1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one Pyridine hydrochloride Aniline hydrochloride Trimethylamine hydrochloride Methylamine hydrochloride Betaine hydrochloride Dimethylamine hydrochloride Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)- (1S,2R)-2-(chloromethyl)-N,N-diethyl-1- phenylcyclopropanecarboxamide (S)-Amlodipine (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide