Human toxicity
originally discovered when it was an unexpected by-product
from the illicit synthesis of a heroin substitute (i.e., meperidine
analog). Currently used experimentally as the primary animal
model for the study of Parkinson’s disease. MPTP is a neurotoxicant
that is activated to 1-methyl-4-phenylpyridinium ion
(MPP1) by the actions of monoamine oxidase B located in the
mitochondria of brain astrocytes. The MPP1 is then transported
into dopamine, and to a lesser extent, other monoaminergic
neurons. Once inside these dopamine neurons in the
substantia nigra, it destroys these neurons by mechanisms that
may involve an oxidative cascade and/or inhibition of electron
transport. Intoxication causes a parkinsonism syndrome almost
identical in signs and symptoms to Parkinson’s disease, including
rigidity, bradykinesia, tremor, and postural instability. In
the event of known ingestion, immediate (but not delayed)
administration of a monoamine oxidase inhibitor (especially
one selective for MAO-B like deprenyl) and dopamine uptake
inhibitor can be therapeutic.
그림문자(GHS):
신호 어:
Danger
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H301
삼키면 유독함
급성 독성 물질 - 경구
구분 3
위험
P264, P270, P301+P310, P321, P330,P405, P501
H370
장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재)
특정 표적장기 독성 - 1회 노출
구분 1
위험
P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P307+P311
노출된 경우,독성 물질 센터 또는 의사에게 전화하기
P321
(…) 처치를 하시오.
P330
입을 씻어내시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE C화학적 특성, 용도, 생산
화학적 성질
Light Yellow Solid
용도
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
정의
ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
신진 대사 경로
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
in a rat pheochromocytoma cell line is oxidized to give
the N-methyl-4-phenylpyridinium ion.
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE 준비 용품 및 원자재
원자재
준비 용품
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE 공급 업체
