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CAY10526

CAY10526 구조식 이미지

카스 번호:: 938069-71-7

상품명:: CAY10526

동의어(영문):: CAY10526;CAY10526 Exclusive;2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-;3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one;WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase

CBNumber:: CB82590422

분자식:: C12H7BrO3S

포뮬러 무게:: 311.15

MOL 파일:: 938069-71-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 45

CAY10526 속성

끓는 점: 561.7±50.0 °C(Predicted)

밀도: 1.889±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml

물리적 상태: 결정성 고체

산도 계수 (pKa): 8.90±0.60(Predicted)

색상: Off-white to yellow

안전

CAY10526 C화학적 특성, 용도, 생산

개요

Prostaglandin E₂ (PGE₂) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE₂ during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE₂ production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE₂ production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC₅₀ value of 1.8 μM without any effect on COX-2 expression.

CAY10526 준비 용품 및 원자재

원자재

준비 용품

CAY10526 공급 업체

글로벌( 45)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	376	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2984	58
Shanghai Han-Xiang Chemical Co., Ltd.	15971444841	amber@biochempartner.com	China	3063	58