Prilocaine
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Prilocaine 속성
- 녹는점
- 37-38°
- 끓는 점
- bp0.1 159-162°
- 밀도
- 1.0117 (rough estimate)
- 굴절률
- nD20 1.5298
- 저장 조건
- 2-8°C
- 용해도
- 물에는 약간 용해되고, 아세톤과 에탄올에는 매우 용해됩니다(96%).
- 산도 계수 (pKa)
- pKa 7.32 or 7.89 (Uncertain)
- 물리적 상태
- Solid
- 색상
- White to off-white
- 수용성
- 6.169g/L(25℃)
- InChI
- InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
- InChIKey
- MVFGUOIZUNYYSO-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=CC=C1C)(=O)C(NCCC)C
- CAS 데이터베이스
- 721-50-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2924296000 | ||
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유해 물질 데이터 | 721-50-6(Hazardous Substances Data) |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Prilocaine C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder.용도
Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.정의
ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.상표명
lidocaine/prilocaine topicalBrand names: Emla, LiproZonePak, Dolotranz, Livixil Pak, and Anodyne LPT.
일반 설명
Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.Pharmacology
Prilocaine is less toxic than lidocaine, with a high clearance, attributable to metabolism in the lungs, kidneys and liver. It is associated with methaemoglobinaemia at doses >600mg. It is sometimes used at a concentration of 0.5% for the provision of intravenous regional anaesthesia, and a combination of prilocaine 3% with felypressin is available for low-volume local infiltration anaesthesia in dental surgery. A 2% formulation is also available for spinal anaesthesia. Prilocaine is also formulated in a eutectic mixture with lidocaine (EMLA) for topical anaesthesia.Clinical Use
Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.Prilocaine 준비 용품 및 원자재
원자재
준비 용품
Prilocaine 공급 업체
글로벌( 432)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12833 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9312 | 58 |
Wuhan Aoliqisi New Material Technology Co., Ltd. | +86-13545906766; +8613545906766 |
sales@whaop.com | China | 263 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3512 | 58 |
Guangzhou Tosun Pharmaceutical Ltd | +86-020-61855200-902 +8618124244216 |
info@upharm.cn | China | 846 | 58 |
Wuhan Biocar Pharmacy CO.,Ltd. | +86-86-13343427080 +8613343427080 |
sales@biocar.cn | China | 209 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3095 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 427 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
sales1@hbganmiao.com | China | 227 | 58 |
Prilocaine 관련 검색:
이소프로필아민 프로필아민 프로피온아미드 알릴아민
(-)-2-[METHYLAMINO]-1-PHENYLPROPANE
Propitocaine hydrochloride
D/L-AMPHETAMINE HYDROCHLORIDE
PRILOCAINE IMPURITY E
PRILOCAINE RELATED COMPOUND B (50 MG) ((RS)-N-(4-METHYLPHENYL)-2-(PROPYLAMINO)PROPANA-MIDE)
(R)-Prilocaine,D-(-)-Prilocaine
(S)-Prilocaine,L-(+)-Prilocaine
Prilocaine
PRILOCAINE HCL USP(CRM STANDARD)
MIXTUREOFAMYLOCAINE,LIGNOCAINE,PRILOCAINE
PRILOCAINE HYDROCHLORIDE IMP. B (EP): 2-METHYLBENZENAMINE (O-TOLUIDINE)
PRILOCAINE IMPURITY E(RS)-N-(METHYLPHENYL)-2-(PROPYLAMINO)PROPANAMIDE EPP(CRM STANDARD)
prilocaine-phenylephrine