CMLD 2,CMLD2;CMLD-2, 10 mM in DMSO;5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-pyrrolidin-1-ylpropyl]-4-phenylchromen-2-one;5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one;2H-1-Benzopyran-2-one, 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-(1-pyrrolidinyl)propyl]-4-phenyl-;5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one(WXC05487)
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CMLD-2 C화학적 특성, 용도, 생산
개요
CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein, disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). It is a coumarin-derived small molecule. CMLD-2 induces apoptosis and exhibits antitumor activity in different cancer cells, such as colon, pancreatic, thyroid and lung cancer cell lines. These biological effects of CMLD-2 could be due to the reduced stability of HuR mRNA targets involved in proliferative and anti-apoptotic pathways. Hu antigen R (HuR) is an RNA-binding protein that can regulate target mRNA stability and translation[1].