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OSW-1

OSW-1 구조식 이미지

카스 번호:: 145075-81-6

상품명:: OSW-1

동의어(영문):: OSW-1;Orsaponin;OSW-1 (Orsaponin);OSW-1, >90% (Orsaponin);16beta-[2-O-Acetyl-3-O-[2-O-(4-Methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3b;(3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one;Cholest-5-en-22-one,16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-b-D-xylopyranosyl]-a-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3b,16b)-;Cholest-5-en-22-one, 16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3β,16β)-;16beta-[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3beta,17alpha-dihydroxycholest-5-en-22-one;(2S,3R,4S,5R)-2-{[(2S,3R,4S,5S)-2-{[(1S,2S,3aS,3bR,7S,9aR,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-1-[(2S)-6-methyl-3-oxoheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-2-yl]oxy}-3-(acetyloxy)-5-hydroxyoxan-4-yl]oxy}-4,5-dihydroxyoxan-3-yl 4-methoxybenzoate

CBNumber:: CB8339904

분자식:: C47H68O15

포뮬러 무게:: 873.03

MOL 파일:: 145075-81-6.mol

속성

안전

용도

공급 업체 43

OSW-1 속성

끓는 점: 932.5±65.0 °C(Predicted)

밀도: 1.31±0.1 g/cm3(Predicted)

저장 조건: Hygroscopic, Refrigerator, under inert atmosphere

용해도: 클로로포름(약간), 메탄올(약간), 피리딘(약간)에 용해됨

산도 계수 (pKa): 12.65±0.70(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 황백색까지

안전

OSW-1 C화학적 특성, 용도, 생산

개요

OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities. It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with K_i values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates. It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells. OSW-1 inhibits replication of a variety of enteroviruses (IC₅₀s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM. It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus. It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM. OSW-1 inhibits growth of HeLa and HEK293 cells (GI₅₀s = 0.33 and 0.22 nM, respectively).

용도

OSW-1 is a unique steroidal saponin displaying selective cytotoxicity against cancer cell lines. From Ornithogalum Saundersiae bulbs.

OSW-1 준비 용품 및 원자재

원자재

준비 용품

OSW-1 공급 업체

글로벌( 43)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2994	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai ruichang pharmaceutical technology co., LTD	18621054990	maychemicals@sina.com	China	673	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2208	55
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61

OSW-1 관련 검색:

OSW-1 ZK-134306