CHROMOMYCIN A3
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CHROMOMYCIN A3 속성
- 녹는점
- 185℃
- 알파
- D23 -57° (ethanol)
- 끓는 점
- 780.13°C (rough estimate)
- 밀도
- 1.1451 (rough estimate)
- 굴절률
- 1.6500 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 에탄올, DMSO 및 에틸 아세테이트(10mg/ml)에 용해됩니다.
- 물리적 상태
- 노란색 고체
- 산도 계수 (pKa)
- 4.54±0.60(Predicted)
- 색상
- 노란색
- Merck
- 13,2258
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T+,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 61-28 | ||
| 안전지침서 | 53-28-36/37/39-45 | ||
| 유엔번호(UN No.) | UN 3462 6.1/PG 1 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | GB7875000 | ||
| F 고인화성물질 | 3-8-10 | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | I | ||
| HS 번호 | 29419090 | ||
| 독성 | Excitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter). |
CHROMOMYCIN A3 C화학적 특성, 용도, 생산
개요
Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios. Chromomycin A3 is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively). It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.화학적 성질
Yellow powder용도
Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.일반 설명
Chemical structure: aureolic acidPurification Methods
Dissolve the antibiotic (10g) in EtOAc and add to a column of Silica Gel (Merck 0.05-0.2microns, 4x70cm) in EtOAc containing 1% oxalic acid. Elute with EtOAc+1% oxalic acid and check fractions by TLC. Pool fractions, wash with H2O thoroughly, dry and evaporate. Recrystallise the residue from EtOAc. The heptaacetate has m 214o, [] D -20o (c 1, EtOH). [Miyamoto et al. Tetrahedron 23 421 1967, Harada et al. J Am Chem Soc 91 5896 1969, Beilstein 17/5 V 673.]CHROMOMYCIN A3 준비 용품 및 원자재
원자재
준비 용품
CHROMOMYCIN A3 공급 업체
글로벌( 105)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 864 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21673 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29826 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 |
CHINA | 2783 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 25859 | 58 |
CHROMOMYCIN A3 관련 검색:
5,6,7,8-테트라하이드로-1-나프톨 뷰틸로인 1'-히드록시-2'-아세토나프톤
AburaMycin A, NSC 131187
CHROMOMYCIN A3
2-Acetyl-6-methoxynaphthalene
2,6-DIMETHYLNAPHTHALENE
Naphthalen-2-ethanol
6-Methoxy-2-heptanonaphthone
6-Methoxy-2-naphthaldehyde
2,3,6-TRIMETHYLNAPHTHALENE
6'-Methoxy-2'-propiononaphthone
ISOVALEROPHENONE
2,6-HEPTANEDIONE
1,6-Dihydroxynaphthalene
2,3-DIMETHYLNAPHTHALENE
6-Hydroxy-2-naphthaldehyde
2,7-DIMETHYLNAPHTHALENE