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E-4031

E-4031 구조식 이미지

카스 번호:: 113559-13-0

상품명:: E-4031

동의어(영문):: E-4031;E4031 diHCl;E-4031 (hydrochloride);E-4031 dihydrochloride, HERG K+ channel blocker;1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid

CBNumber:: CB8384065

분자식:: C21H33Cl2N3O5S

포뮬러 무게:: 510.47

MOL 파일:: 113559-13-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 83

E-4031 속성

저장 조건: -20°C

용해도: H2O: 용해성

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 회백색

안정성: 흡습성

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

WGK 독일	3

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330	입을 씻어내시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
2		0

E-4031 C화학적 특성, 용도, 생산

용도

E-4031 has been used as:

human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
IKr blocker in rat ventricular myocytes

생물학적 활성

Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

E-4031 준비 용품 및 원자재

원자재

준비 용품

E-4031 공급 업체

글로벌( 83)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9026	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

E-4031 관련 검색:

N-Methylbenzylamine N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE 4-BENZOYLPIPERIDINE HYDROCHLORIDE Betahistine dihydrochloride N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE E-4031,E-4031 DIHYDROCHLORIDE 4-(4-PIPERIDINYLMETHYL)-BENZENAMINE 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE E-4031 2-(2'-AMINOETHYL)-6-METHYLPYRIDINE RARECHEM AL F1 4031 AURORA KA-4031 RARECHEM AK PP 4031 AKOS BB-4031 AURORA 4031 E-4031, Voltage-Gated (HERG) K+ Channel Blocker, 510.48MW