세룰로플라민,인간
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세룰로플라민,인간 속성
- 저장 조건
- -20°C
- 물리적 상태
- 생리 식염수
안전
위험품 표기 | B | ||
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WGK 독일 | 3 |
세룰로플라민,인간 C화학적 특성, 용도, 생산
정의
A copper-containing alpha globulin in blood plasma that contains type 1, type 2, and type 3 copper cen- ters in which the type 2 and type 3 centers are near each other, constituting a trinuclear copper cluster. It may play a part in red blood cell production and oxygen reduction.Pharmaceutical Applications
Typically, 50% of the daily copper intake is absorbed in theGI tract and transported to the liver from where it is transported to the peripheral tissue bound to ceruloplasmin, acopper-binding glycoprotein. A smaller amount of copper is also bound to albumin. Excess copper is mainly excreted in bile into the gut and then the faeces.Ceruloplasmin (ferroxidase I) and ferroxidase II, two copper-based enzymes, can oxidise ferrous iron to ferric iron. Ferric iron can then be transported with the help of transferrin,for example, to form red blood cells. Furthermore, a variety of copper-dependent enzymes, such as cytochrome c and superoxide dismutase, work as antioxidants and are involved in the reduction of reactive oxygen species (ROS).
Cancer progression has been linked to increased ceruloplasmin and copper levels in a variety of tissues.Copper deficiency has been considered as an anticancer strategy, but several clinical studies have not been encouraging.
Biochem/physiol Actions
Ceruloplasmin (Cp), the principal carrier of copper in plasma, is thought to be involved in oxidative modification of lipoproteins and participate in the acute phase reaction to stress. Cp is an effective antioxidant for a variety of radicals and has a potent peroxidase activity to decompose hydrogen peroxide in the presence of reduced glutathione. It inhibits the peroxidase activity of myeloperoxidase in a concentration-dependent manner and shows selective binding to myeloperoxidase in vitro. This suggests that ceruloplasmin may participate in the clearance and inactivation of myeloperoxidase in vivo. At physiological (micromolar) concentrations it was found to inhibit relaxation of rabbit aorta induced by endothelium-dependent agonists like acetylcholine or ADP. However, it was found ineffective toward vasodilation due to direct stimulation of smooth muscle cells by nitroglycerin. Cp plays an essential role in iron homeostasis, regulating the efflux of iron from macrophages and the oxidation of Fe2+ to Fe3+. Cp deficiency leads to neurodegenerative disorders, possibly by starving neurons of iron.세룰로플라민,인간 준비 용품 및 원자재
원자재
준비 용품
세룰로플라민,인간 공급 업체
글로벌( 29)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Anhui kuer Bioengineering Co., Ltd | 0551-65171243 13810511747 |
kuer@kuerhuaxue.com | China | 2997 | 55 |
Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 |
alan.chow@synzest.com | China | 9471 | 58 |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 |
1046@dideu.com | China | 10011 | 58 |
Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-021-59178156 17002132182 |
3146474380@qq.com | China | 11609 | 58 |
Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 |
1986399151@qq.com | China | 9849 | 58 |
세룰로플라민,인간 관련 검색:
아세틸아세톤산 구리 실버 아세틸아세토네이트 코발트(II) 아세틸아세토네이트 하이드레이트 알루미늄 아세틸아세토네이트 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세토산 제2철
Tris(2,4-pentanedionato)chroMiuM(III)
N-BUTYLISOCYANIDE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
Tosylmethyl isocyanide
SALCOMINE
TERT-BUTYL ISOCYANIDE
PHENYLSELENOL
METHYL ISOCYANOACETATE
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
Ethyl isocyanoacetate
Benzyl isocyanide