diABZI STING agonist-1 trihydrochloride
|
|
diABZI STING agonist-1 trihydrochloride 속성
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: 50 mg/ml
- 물리적 상태
- 결정성 고체
- 색상
- White to yellow
- InChIKey
- PSJURLIZOBGEGB-HRNDJLQDSA-N
- SMILES
- C(N1C(=NC2=CC(C(=O)N)=CC(OCCCN3CCOCC3)=C12)NC(C1=CC(C)=NN1CC)=O)/C=C/CN1C(=NC2=CC(C(=O)N)=CC(OC)=C12)NC(C1=CC(C)=NN1CC)=O.Cl
안전
diABZI STING agonist-1 trihydrochloride C화학적 특성, 용도, 생산
개요
diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC50 = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.diABZI STING agonist-1 trihydrochloride 준비 용품 및 원자재
원자재
준비 용품
diABZI STING agonist-1 trihydrochloride 공급 업체
글로벌( 61)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32302 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38672 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 52924 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 5221 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 5620 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 |
China | 4645 | 55 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 |
sales-cpd@caerulumpharma.com | China | 3478 | 58 |