가나솔론
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가나솔론 속성
- 녹는점
- 190-192°
- 알파
- D +103°
- 끓는 점
- 434.8±18.0 °C(Predicted)
- 밀도
- 1.036±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ~4.2mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 15.18±0.70(Predicted)
- 색상
- 하얀색
안전
안전지침서 | 22-24/25 | ||
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WGK 독일 | 3 | ||
RTECS 번호 | TU4384700 |
가나솔론 C화학적 특성, 용도, 생산
개요
Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.용도
Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.생물학적 활성
Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.가나솔론 준비 용품 및 원자재
원자재
1-((2R,10S,13S,17S)-10,13-dimethylhexadecahydrospiro[cyclopenta[a]phenanthrene-3,2-oxiran]-17-yl)ethanone(WXG00316)
알로프레그나놀론
5α-Pregnane-3,20-dione
메틸마그네슘브로마이드
Pregnenolone
메틸마그네슘 염화물
준비 용품
가나솔론 공급 업체
글로벌( 67)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hunan Yuanye Pharmaceutical Co., Ltd. | +8615857615745 |
2675013845@qq.com | China | 87 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29821 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
Hunan Well Medicine Synthesis Technology Co., Ltd | 0731-85589467 13574065797 |
2675013845@qq.com | China | 33 | 58 |
Bayee Biotech (Anqing) Co., Ltd. | 0556-5032306 18917961636 |
wtx@bayeebio.com | China | 246 | 61 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |