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P405
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NFPA 704
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트랜스-23-다이메톡시-베타-니트로스티렌 C화학적 특성, 용도, 생산
Biochem/physiol Actions
CID 5380390 (trans-2,3-Dimethoxy-?-nitrostyrene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcription, chromatin modification, and signal transduction. CID 5380390 has an IC50 values of 23 μM for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases.
