DMT-2′Fluoro-dU Phosphoramidite
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DMT-2′Fluoro-dU Phosphoramidite 속성
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.39±0.10(Predicted)
- 색상
- 흰색에서 황백색까지
- InChIKey
- HQHQPAYRJJMYQX-YOKGOYKLNA-N
- SMILES
- N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r|
안전
WGK 독일 | 3 |
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DMT-2′Fluoro-dU Phosphoramidite C화학적 특성, 용도, 생산
정의
DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNASynthesis
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).DMT-2′Fluoro-dU Phosphoramidite 준비 용품 및 원자재
원자재
준비 용품
DMT-2′Fluoro-dU Phosphoramidite 공급 업체
글로벌( 172)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hefei Huana Biomedical Technology Co.,Ltd. | +86-15900695956 |
shiqin.he@huanaok.com.cn | China | 96 | 58 |
Allbiosyn Biotechnology Co.,Ltd. | +8618666985712 |
info@allbiosyn.com | China | 255 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16208 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10318 | 58 |
Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 |
yunbiochem@126.com | China | 321 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
DMT-2′Fluoro-dU Phosphoramidite 관련 검색:
(3-클로로프로필)트리메톡시실란 3-(트라이에톡시실릴)프로필아민 5-플루오로-2'-디옥시유리딘 우리딘
Doxifluridine
1-beta-D-Arabinofuranosyluracil
Pseudouridine
3-Chloropropyltriethoxysilane
5-Fluorouridine
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DMT-dA(bz) Phosphoramidite
DMT-2'O-Methyl-rU Phosphoramidite
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DMT-dG(dmf) Phosphoramidite
3'-TBDMS-ibu-rG Phosphoramidite
Ac-rC Phosphoramidite
DMT-2′Fluoro-dU Phosphoramidite