Tocainide hydrochloride

Tocainide hydrochloride 구조식 이미지
카스 번호:
35891-93-1
상품명:
Tocainide hydrochloride
동의어(영문):
Xylotocan;TOCAINIDE HCL;Unii-2K7I38ckn5;tonocardhydrochloride;tocainide hydrochloride;TOCAINIDE HYDROCHLORIDE (125 MG);Tocainide hydrochloride USP/EP/BP;Tocainide Hydrochloride (1667552);2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride;2-amino-n-(2,6-dimethylphenyl)-propanamidmonohydrochloride
CBNumber:
CB8500546
분자식:
C11H17ClN2O
포뮬러 무게:
228.71848
MOL 파일:
35891-93-1.mol

Tocainide hydrochloride 속성

녹는점
244-245°C
저장 조건
-20°C Freezer
용해도
메탄올(약간 용해됨), 물(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
색상
회백색

안전

HS 번호 2924296000

Tocainide hydrochloride C화학적 특성, 용도, 생산

용도

Tonocard(AstraZeneca).

일반 설명

Tocainide hydrochloride,2-amino-2' ,6 '-propionoxyxylidide hydrochloride (Tonocard)(pKa 7.7), is an analog of lidocaine. It is orally active and haselectrophysiological properties like those of lidocaine. Totalbody clearance of tocainide hydrochloride is only166 mL/min, suggesting that hepatic clearance is not large.Because of low hepatic clearance, the hepatic extraction ratiomust be small; therefore, tocainide hydrochloride is unlikelyto be subject to a substantial first-pass effect. The drug differsfrom lidocaine, in that it lacks two ethyl groups, which providestocainide hydrochloride some protection from first-passhepatic elimination after oral ingestion. Tocainide hydrochlorideis hydrolyzed in a manner similar to that of lidocaine.None of its metabolites is active.

Clinical Use

Tocainide hydrochloride is classed as a IB antiarrhythmicagent and used orally to prevent or treat ventricular ectopyand tachycardia. The drug is given in 400- to 600-mgdoses every 8 hours.

Tocainide hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Tocainide hydrochloride 공급 업체

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InvivoChem
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Shanxi New Baoyuan Pharmaceutical Co., Ltd. 0352-7606558
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Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
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Boen pharm 86 512-62572107 62962707
China 800 58

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