4-formyl-3-methoxybenzonitrile
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4-formyl-3-methoxybenzonitrile 속성
- 녹는점
- 109-111℃
- 끓는 점
- 318℃
- 밀도
- 1.18
- 증기압
- 0.003-2.3Pa at 20-80℃
- 인화점
- 138℃
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- InChI
- InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
- InChIKey
- ZXENVSJZOHXCKL-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(C=O)C(OC)=C1
- LogP
- 1.42 at 20℃ and pH7
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): |
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신호 어: | Danger | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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4-formyl-3-methoxybenzonitrile C화학적 특성, 용도, 생산
용도
4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.Synthesis
79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde is obtained as a white solid.![4-CYANO-2-METHOXYBENZALDEHYDE 4-CYANO-2-METHOXYBENZALDEHYDE](/NewsImg/2023-11-28/6383678639152906027639808.jpg)
4-formyl-3-methoxybenzonitrile 준비 용품 및 원자재
원자재
Benzonitrile, 4-(hydroxymethyl)-3-methoxy-
벤조일클로라이드,4-시아노-2-메톡시-(9Cl)
벤조일클로라이드,3-메톡시-4-메틸-(9CI)
3-Methoxy-4-methylbenzoic acid
4-DibroMo메틸-3-메톡시벤조니트릴
4-Bromo-2-hydroxybenzoic acid
3-Iodophenol
2-HYDROXY-4-IODO-BENZALDEHYDE
3-메톡시4-메틸렌조니트릴
4-Iodo-2-methoxybenzaldehyde
4-히드록시-3-메톡시벤조니트릴
4-브로모-2-메톡시벤잘데하이드
메틸4-브로모-2-메톡시벤조에이트98
준비 용품
4-formyl-3-methoxybenzonitrile 공급 업체
글로벌( 298)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 |
tracy.li@zisonpharm.com | China | 57 | 58 |
Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 |
info@chemsigma.com | China | 1229 | 58 |
Shanghai Famo Biotech Co Ltd | +8618550473860 |
mayan@famobiotech.com | China | 525 | 58 |
Suzhou Nordica Biopharma CO.,LTD | +8618136148818 |
anna.ran@nordicabio.com | China | 298 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12448 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 988 | 58 |
Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 |
info@millionpharm.com | China | 203 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |