미리스틱 알코올 (N-테트라데칸올)

미리스틱 알코올 (N-테트라데칸올) 속성

미리스틱 알코올 (N-테트라데칸올) C화학적 특성, 용도, 생산

용도

화장품의피부연화제,계면활성제.

화학적 성질

white low melting solid or flakes

용도

1-Tetradecanol is used as an ingredient in cosmetics such as cold creams. It is an active intermediate in the chemical synthesis of sulfated alcohol. It is also employed in the fabrication of temperature-regulated drug release system based on phase-change materials. It plays a vital role in filling the hollow interiors of gold nanocages in the fabrication of new theranostic system, which has unique feature of photoacoustic imaging.

생산 방법

Myristyl alcohol is found in spermaceti wax and sperm oil, and may be synthesized by sodium reduction of fatty acid esters or the reduction of fatty acids by lithium aluminum hydride. It can also be formed from acetaldehyde and dimethylamine.

정의

ChEBI: 1-Tetradecanol is a long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group It is a long-chain primary fatty alcohol, a fatty alcohol 14:0 and a primary alcohol.

제조 방법

1-Tetradecanol is prepared from the head oil of the Sperm Whale via the acid and the ester.

일반 설명

Colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water.

공기와 물의 반응

Insoluble in water.

반응 프로필

1-Tetradecanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

건강위험

Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation.

Pharmaceutical Applications

Myristyl alcohol is used in oral, parenteral, and topical pharmaceutical formulations. It has been evaluated as a penetration enhancer in melatonin transdermal patches in rats.
Myristyl alcohol has also been tested as a bilayer stabilizer in niosome formulations containing ketorolac tromethamine,and zidovudine.Niosomes containing myristyl alcohol showed a considerably slower release rate of ketorolac tromethamine than those containing cholesterol.This was also observed with the zidovudine formulation.

Safety

Myristyl alcohol is used in oral parenteral, and topical pharmaceutical formulations. The pure form of myristyl alcohol is mildly toxic by ingestion and may be carcinogenic; experimental tumorigenic data are available.It is also a human skin irritant. In animal studies of the skin permeation enhancement effect of saturated fatty alcohols, myristyl alcohol exhibited a lower effect when compared with decanol, undecanol, or lauryl alcohol but caused greater skin irritation.A study investigating contact sensitization to myristyl alcohol revealed that patch testing of myristyl alcohol 10% petrolatum should not be carried out owing to observed irritant effects; thus the use of a lower concentration of myristyl alcohol for such tests (5% petrolatum) was recommended.Myristyl alcohol has been associated with some reports of contact allergy.(8,9)A moderate-to-severe erythema and moderate edema are seen when 75 mg is applied to human skin intermittently in three doses over 72 hours.
LD₅₀(rabbit, skin): 7.1 g/kg
LD₅₀(rat, oral): 33.0 g/kg

저장

The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH. It has also been purified by zone melting. [Beilstein 1 IV 1864.]

비 호환성

Myristyl alcohol is combustible when exposed to heat or flame. It can react with oxidizing materials. When heated to decomposition, it emits acrid smoke and irritating fumes.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablet: sustained-release; and topical formulations: cream, lotion, suspension). Included in nonparenteral (topical cream) formulations licensed in the UK.

미리스틱 알코올 (N-테트라데칸올) 준비 용품 및 원자재

원자재

준비 용품

미리스틱 알코올 (N-테트라데칸올) 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5892	58
Shandong Dexiang International Trade Co., Ltd	+86-15662691337 +86-15662695772	539942812@qq.com	China	998	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Hebei Yime New Material Technology Co., Ltd.	+86-66697723 +86-17703311139	admin@china-yime.com	China	563	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2986	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58

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