토코레티네이트

토코레티네이트
토코레티네이트 구조식 이미지
카스 번호:
40516-48-1
한글명:
토코레티네이트
동의어(한글):
토코레티네이트
상품명:
Tocoretinate
동의어(영문):
N 021;L 300;Olcenon;TOCORETINATE;tretinoin tocoferil;dl-α-Tocopheryl Retinoate;dl-a-Tocopheryl Retinoate;VITAMIN E VITAMIN A ACID ESTER;Retinoic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester, (±)-;Retinoic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, [2R*(4R*,8R*)]-(+-)-
CBNumber:
CB8700933
분자식:
C49H76O3
포뮬러 무게:
713.13
MOL 파일:
40516-48-1.mol

토코레티네이트 속성

끓는 점
761.3±60.0 °C(Predicted)
밀도
0.959±0.06 g/cm3(Predicted)
CAS 데이터베이스
40516-48-1(CAS DataBase Reference)

안전

독성 LD50 in mice (mg/kg): >1000 i.v.; >2000 orally (Fukawa, 1975)

토코레티네이트 C화학적 특성, 용도, 생산

개요

Tretinoin tocoferil, the a-tocopherol ester of all-trans-retinoic acid, was launched for the treatment of bedsores and skin ulcers such as burn, leg, and diabetic ulcers. It is also an orally active agent for gastric ulcer treatment. Tretinoin tocoferil represents a new class of antiulcer drugs which act by directly promoting tissue repair, distinguished from common drugs that exert an indirect function by suppression of acid-secretion and mucosa protection. The mode of its action has been proposed to relate to its ability to stimulate DNA synthesis of growth-arrested human skin fibroblasts by promoting expression of the epidermal growth factor receptor.

용도

dl-α-Tocopheryl Retinoate is an α-tocopherol ester of all-trans retinoic acid (R250200) and is safely used in the treatment of skin ulcer. ?dl-α-Tocopheryl Retinoate inhibited proliferation of human promyelocytic leukemia HL-60 cells and induced granulocytic differentiation of the cells, but to a lesser extent than did retinoic acid.

토코레티네이트 준비 용품 및 원자재

원자재

준비 용품


토코레티네이트 공급 업체

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