azapropazone C화학적 특성, 용도, 생산
화학적 성질
Nearly colorless, crystalline solid.
용도
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
정의
ChEBI: A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group o
propylmalonic acid.
World Health Organization (WHO)
Azapropazone, which has anti-inflammatory, analgesic and
antipyretic activity, was introduced in 1970 for the treatment of rheumatic
disorders. Although sometimes classified as a pyrazolone derivative, the
relationship with this group of compounds has been disputed and classification as
a benzotriazine derivative might be preferable. Although, to date, it has not been
associated with blood dyscrasias, some regulatory authorities have applied the
same rigorous restrictions to its indications as they have applied to pyrazolone
derivatives. The World Health Organization was informed that as of December 1987
azapropazone was available in some 27 countries.
위험도
Nausea, vomiting, abdominal pain, gastric ulcers; moderately toxic.
Safety Profile
Moderately toxic by ingestion,intraperitoneal and intravenous routes. When heated todecomposition it emits toxic fumes of NOx.
Synthesis
Synthesis: a mixture of 1,2-dihydro-3-dimethylamino-7-methylbenzotriazine, diethyl
propylmalonate, and sodium ethoxide in xylene is heated over a period of time to 150 ?C,
cooled, and acidified to give the desired product.
azapropazone 준비 용품 및 원자재
원자재
준비 용품
