셀레콕시브
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셀레콕시브 속성
안전
셀레콕시브 C화학적 특성, 용도, 생산
Originator
Celact,Sun Pharmaceuticals Industries Ltd.,IndiaManufacturing Process
4-(5-(4-Methylphenyl)-3-trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide To a solution of ethyl trifluoroacetate (1.90 ml, 16.0 mmol) in 7 ml of methyl tert-butyl ether was added 25% NaOMe (3.62 ml, 16.8 mmol). Next 4- chloroaceteophenone (2.08 ml, 16.0 mmol) in 2 ml of methyl tert-butyl ether was added. The mixture was stirred at room temperature overnight. To above solution was added 100 ml of 90% EtOH, followed by 4 N HCl (4.0 ml, 16 mmol) and 4-sulphonamidophenylhydrazine hydrochloride (3.58 g, 16 mmol). The mixture was heated to reflux for 3 hours. The mixture was concentrated. When 30 ml of water was added, a solid formed. The solid was filtered and washed with 20 ml of 60% EtOH to give 4.50 g of white solid. The filtrate was evaporated and taken up in ethyl acetate (100 ml), washed with saturated NaHCO3, and brine, dried over MgSO4, and concentrated. Heptane was added at boiling point of the mixture. After cooling down to 0°C, 1.01 g more product was obtained. The combined yield of the 4-(5-(4-methylphenyl)-3- trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide (Celecoxib) was 86%.Therapeutic Function
Antiinflammatory셀레콕시브 준비 용품 및 원자재
원자재
준비 용품
셀레콕시브 공급 업체
글로벌( 14)공급 업체
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Alfa Chemistry | +1-5166625404 |
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Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
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Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 |
sales@anikare.com | China | 8570 | 58 |
China Nobel Chem Co., Limited | +86(0)21 60484900 |
China | 764 | 50 | |
Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 |
China | 9767 | 58 | |
Nanjing crow LuNing pharmaceutical technology co., LTD | 13382066392 |
CHINA | 4880 | 58 | |
Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 |
amber@biochempartner.com | China | 3063 | 58 |
Wuhan kemike Biomedical Technology Co., Ltd | 027-13163388153 13163388153 |
yeqiu416@163.com | China | 9970 | 58 |
Zhongxin Chenshi (Wuhan) Technology Co., Ltd | 18942922096 |
2662561040@qq.com | China | 1001 | 58 |