Fmoc-Lys(Ddiv)-OH
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Fmoc-Lys(Ddiv)-OH 속성
- 끓는 점
- 765.6±60.0 °C(Predicted)
- 밀도
- 1.183±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 산도 계수 (pKa)
- 3.88±0.21(Predicted)
- 물리적 상태
- 가루
- 색상
- 하얀색
- InChIKey
- PYCBVLUBTMHNPW-MHZLTWQESA-N
- SMILES
- C(O)(=O)[C@H](CCCCN/C(=C1/C(=O)CC(C)(C)CC/1=O)/CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| F 고인화성물질 | 10-21 | ||
| HS 번호 | 2924 29 70 |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Fmoc-Lys(Ddiv)-OH C화학적 특성, 용도, 생산
개요
Fmoc-lys(IVDDE)-OH is a kind of FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It is important during peptide manufacturing. It is mainly used for the production of peptides which required to be modified on the Lysine side chain, including peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys side chain. It can also be used for the manufacturing of anionic cell penetrating peptide which is useful for intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed thorough hydrazine in the presence of acid labile groups.화학적 성질
White to pale yellow powder용도
Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.Advantages
Fmoc-Lys(ivDde)-OH could be used to synthesize hetero-branched peptidesto avoid homodimer generation and construct heterodimers with a high ratio. This agent was used to generate Cellpenetrating peptides (CPP) and candidate peptides in one molecule[1].참고 문헌
Wen-Qu, L. I., X. U. Hong-Yan, and L. I. Zhan-Xiong. "Synthesis of End N-Ivdde Protected Amino Acid."Chinese Journal of Synthetic Chemistry 17.2(2009):213-215.http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid.php?id=101224
Chen, Hui Ting, et al. "Anionic cell penetrating peptide and its use for intracellular delivery." US, US8614194. 2013.
[1] Kozaki L, et al. Disulfide linked hetero dimeric peptide arrays for screening functional peptides inside cells. Journal of Bioscience and Bioengineering, 2019; 129: 613-618.
Fmoc-Lys(Ddiv)-OH 준비 용품 및 원자재
원자재
준비 용품
Fmoc-Lys(Ddiv)-OH 공급 업체
글로벌( 210)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 |
sales@alabiochem.com | China | 888 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8617390183901 |
daisy@enlaibio.com | China | 1358 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16221 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9338 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
| GenicBio Limited | +86-21-37621270 |
service@genicbio.com | CHINA | 991 | 58 |
| career henan chemical co | +86-0371-55982848 +86-15093356674 |
sales@coreychem.com | China | 29901 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7154 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Fmoc-Lys(Ddiv)-OH 관련 검색:
Fmoc-L-Lys(Dde)-OH
(s)-3-(fmoc-amino)-n-trityl-adipic acid 6-amide
FMoc-Lys-AMC.HCl
FMOC-L-LYS(DANSYL)-OH
Fmoc-Lys(N3)-OH
FMoc-Aea-OH
N(ALPHA)-FMOC-N(EPSILON)-DABCYL-L-LYSINE
FMOC-LYS(BOC)(ME)-OH
FMOC-LYS(ME)2-OH HCL
FMOC-LYS(DNP)-OH
Fmoc-Lys(Trt)-OH
FMOC-LYS(ME3)-OH HCL
N-Boc-N'-Fmoc-L-Lysine
L-Fmoc-Aspartic acid alpha-tert-butyl ester
N-Boc-N'-Fmoc-D-lysine
FMOC-D-ASP-OTBU
FMOC-D-GLU-OTBU
FMOC-D-LYS(IVDDE)-OH