Tirofiban
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Tirofiban 속성
- 녹는점
- 223-225°
- 끓는 점
- 611.7±65.0 °C(Predicted)
- 밀도
- 1.154±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 용해도
- Limited solubility
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 3.37±0.10(Predicted)
- 색상
- White to off-white
- BRN
- 6182267
- CAS 데이터베이스
- 144494-65-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26 | ||
WGK 독일 | 3 | ||
RTECS 번호 | YP2364100 | ||
유해 물질 데이터 | 144494-65-5(Hazardous Substances Data) |
그림문자(GHS): | |||||||||||||||||||||||||||||
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Tirofiban C화학적 특성, 용도, 생산
화학적 성질
Tirofiban is an Off-White to Pale Yellow Solid. It is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of tirofiban in these solvents is approximately 30 mg/ml.용도
Tirofiban (Aggrastatt, MK-0383; L-700,462) is a parenteral, highly specific, and potent GPIIb/IIIa antagonist that was approved for patient use in 1998 for the treatment of unstable angina and non-Q-wave myocardial infarction.Tirofiban is a nonpeptide GP IIb/IIIa antagonist that binds reversibly to IIb/IIIa receptors. Tirofiban is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIbIIIa receptor used as an antiplatelet drug.
Tirofiban is a small molecule inhibitor of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins can be traced to a pharmacophore-based virtual screening lead.
정의
ChEBI: Tirofiban is a member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. It has a role as a fibrin modulating drug, a platelet glycoprotein-IIb/IIIa receptor antagonist and an anticoagulant. It is a member of piperidines, a sulfonamide and a L-tyrosine derivative.일반 설명
Tirofiban is a nonpeptide that appears unrelatedchemically to eptifibatide, but actually has many similarities.The chemical architecture incorporates a systemthat is mimicking the RGD moiety that is present in eptifibatide.This can be seen in the distance between the nitrogenof the piperidine ring, which mimics the basic nitrogen ofarginine in the RGD sequence, and the carboxylic acid,which mimics the acid of aspartate in the RGD sequence.The basic nitrogen and the carboxylic acid of tirofiban areseparated by approximately 15 to 17? (16–18 atoms). Thisis the optimum distance seen in the RGD sequence of theplatelet receptor. Tirofiban is useful in treating non–Q wavemyocardial infarction and unstable angina.Clinical Use
Tirofiban is a member of a new class of antithrombotic agents known as the “ fibans”. These compounds have a structural similarity to disintegrin, which was originally isolated from snake venoms. The location of the –COO- and NH3+ in the fibans is identical to the distance between the same functional groups of the RGD loop of disintegrin, and as a result, the fibans are able to effectively block the binding of fibrinogen to the GPIIb/IIIa receptor in an reversible manor.Mode of action
Tirofiban is a reversible antagonist that inhibits platelet aggregation by reversibly binding to the receptor glycoprotein (GP) IIb/IIIa of human platelets, thus preventing the binding of fibrinogen. Inhibition of platelet aggregation occurs in a dose- and concentrationdependent manner.?Tirofiban 준비 용품 및 원자재
원자재
1-Butanesulfonyl chloride
L-(-)-티로신
N-메틸아세트아마이드
셀룰로스
이소 프로필 아세테이트
테트라하이드로푸란
1-브로모-3-클로로프로페인
황산 칼륨
부틸리튬
γ-피콜린
Palladium hydroxide
3-Butyn-1-ol, 4-(4-pyridinyl)- (9CI)
4-(4-클로로부틸)피리딘
N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine
에틸L-티로네이트
준비 용품
Tirofiban 공급 업체
글로벌( 159)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2136 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-15319487004 |
1015@dideu.com | China | 2132 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Tirofiban 관련 검색:
드로페리돌, 펜타닐 페닐 살리실산 할로페리돌 2,2,6,6-사메틸-4-피페리디놀 프로피온산 부틸디페닐클로로실란 디페닐에테르 페닐초산
N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine
4-(4-pyridinyl)butyl chloride hydrochloride
PHENYL VALERATE
Lithium tri-tert-butoxyaluminum hydride
R-Tirofiban
Tirofiban Impurity 3
PHENYL RESIN
4-BUTYLPIPERIDINE
Tirofiban Impurity 9
Tirofiban Impurity 11